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International Journal of Endocrinology
Volume 2015, Article ID 185859, 9 pages
Research Article

Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes

1Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic
2Department of Psychology, Faculty of Arts, Charles University in Prague, 11000 Prague, Czech Republic
3Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, 11800 Prague, Czech Republic
4Department of Social Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50038 Hradec Kralove, Czech Republic

Received 8 October 2014; Accepted 28 November 2014

Academic Editor: Nikolaos Papanas

Copyright © 2015 Alena Spirkova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type 1 diabetes (T1D) in children and adolescents is relatively often accompanied by other immunopathological diseases, autoimmune thyroid disease (AITD) or celiac disease (CD). Our aim was to assess whether these conditions are associated with changes in the health-related quality of life (HRQOL) in pediatric patients with T1D. In a cross-sectional study we identified eligible 332 patients with T1D aged 8–18 years, of whom 248 (75%) together with their parents responded to the PedsQL Generic and Diabetes Modules. Compared to 143 patients without thyroid autoantibodies, 40 patients with a thyroxine-treated AITD scored lower in the overall generic HRQOL , as well as in the overall diabetes-specific HRQOL . After adjustment for age, gender, duration of diabetes, type of diabetes treatment, and diabetes control, this association remained statistically significant for the generic HRQOL . Celiac disease was not associated with a change in the generic or diabetes-specific HRQOL (, resp.). Parental scores showed no association with AITD or celiac disease, except a marginally significant decrease in the overall generic HRQOL in the T1D + AITD compared to T1D group. Our study indicates that, in pediatric patients with T1D, concomitant thyroxine-treated AITD is associated with lower quality of life.