Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice

Table 2

Incidence of lung tumors in castrated BALB/c female mice of the study groups in accordance with the tumor diameter.

Groups	Data of mice after 6 months
		Tumors per mouse in accordance with tumor diameter (m ± SEM)
		All	<1.0 (mm)	1.0 to 2.0 (mm)	>2.0 (mm)
Intact control	15	0	0	0	0
Ovariectomized control	12	0	0	0	0
Intact urethane-treated	10	6.5 ± 0.79	4.1 ± 0.6	2.0 ± 0.45	0.4 ± 0.31
Ovariectomized urethane-treated	12	6.0 ± 0.63	3.5 ± 0.69	2.17 ± 0.41	0.33 ± 0.26
Intact urethane-NaVP-treated	13	8.15 ± 0.55	5.0 ± 0.47	3.08 ± 0.51	0.08 ± 0.08
Ovariectomized urethane-NaVP-treated	14	8.29 ± 0.5	3.86 ± 0.44	3.71 ± 0.5	0.71 ± 0.29
Intact NaVP-treated	15	0	0	0	0
Ovariectomized NaVP-treated	15	0	0	0	0

< 0.02 in comparison with the ovariectomized urethane-treated group.
< 0.05 in comparison with the ovariectomized urethane-treated group.