Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice

Table 3

Number of adenomas and adenocarcinomas in experimental mice groups.

Group		Number of tumors
		Adenocarcinoma		Adenoma		Adenocarcinoma + adenoma
		Median (range)	Total	Median (range)	Total	Median (range)	Total
Intact control	15	0	0	0	0	0	0
Ovariectomized control	12	0	0	0	0	0	0
Intact urethane-treated	10	2 (0–6)	25	0 (0–2)	5	4 (1–7)	30
Ovariectomized urethane-treated	12	4 (1–6)	44	1 (0–3)	15	5.5 (2–7)	59
Intact urethane-NaVP-treated	13	4 (0–10)	47	1 (0–4)	18	6 (1–11)	65
Ovariectomized urethane-NaVP-treated	14	2.5 (1–5)	33	1 (0–7)	28	4 (1–10)	61
Intact NaVP-treated	15	0 (0-1)	1	0	0	1 (0-1)	1
Ovariectomized NaVP-treated	15	0	0	0	0	0	0

in comparison with ovariectomized urethane-treated (Mann-Whitney test).
comparing the median value of adenocarcinoma number with the adenoma in the intact urethane-treated group.
comparing the median value of adenocarcinoma with the adenoma in the intact urethane-NaVP-treated group.
comparing the median value adenocarcinoma number with the adenoma in the ovariectomized urethane-treated group.