The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

Figure 7

The AC stimulating effects of agonists of adrenergic receptors in the myocardium of diabetic and nondiabetic rats and the influence of IS treatment. a—norepinephrine, b—isoproterenol, c—BRL-37344, and d—CL-316243 (all were used at a concentration of 10⁻⁵ M). The AC stimulating effect was expressed as hormone-induced increase of AC activity over the basal enzyme activity, pmol cAMP/min per mg of membrane protein. The data are presented as M SD. (, ) The difference between Groups C0 and D0 and (#, ##) the difference between Groups C0 and ND + SER or between Groups D0 and D + SER are significant at and , respectively.