The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes
Table 1
The body weight and the plasma level of fasting glucose and insulin in control and diabetic rats and the influence of the treatment with IS.
Start point of the experiment, 0 day
60th day (two-month HFD)
90th day (before IS treatment)
150th day (before decapitation)
Group C ()
Group C0 ()
Weight, g
181 ± 8
298 ± 15
337 ± 14
359 ± 22
Glucose, mM
4.0 ± 0.2
4.0 ± 0.3
4.3 ± 0.3
3.8 ± 0.3
Insulin, ng/mL
ND
0.56 ± 0.17
ND
0.67 ± 0.15
Group ND + SER ()
Weight, g
—
419 ± 29#
Glucose, mM
—
4.5 ± 0.3#
Insulin, ng/mL
—
0.84 ± 0.21
Group D ()
Group D0 ()
Weight, g
186 ± 7
372 ± 18
410 ± 20
457 ± 19
Glucose, mM
3.9 ± 0.2
5.5 ± 0.5
7.8 ± 1.0
6.9 ± 0.8
Insulin, ng/mL
ND
0.74 ± 0.15
ND
0.76 ± 0.16
—
Group D + SER ()
Weight, g
—
429 ± 25#
Glucose, mM
—
5.2 ± 0.5##
Insulin, ng/mL
—
0.73 ± 0.11
Note. All values are presented as M ± SD. () The difference between Groups C and D and between Groups C0 and D0 and () the difference between Groups C0 and ND + SER or between Groups D0 and D + SER are significant at and , respectively.
