Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice

Figure 1

FGF21 improves glucose tolerance in normal mice. (a) Glucose tolerance testing in normal mice. (b) Glucose tolerance testing in bGH transgenic mice. Glucose levels were measured at indicated times after i.p. injection with a bolus of glucose (2 g/kg body weight). Data are mean ± SD. versus vehicle-treated group (2-tailed, unpaired, homoscedastic Student’s -test).

(a)

(b)