Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice

Table 1

Body weight and plasma constituent parameters in control and GH transgenic mice.

Parameters	Normal		Transgenic
	PBS	FGF21	PBS	FGF21
Body weight (g)	29.9 ± 2.3^a	29.8 ± 1.0^a	55.3 ± 0.8^b	51.2 ± 4.0^b
Fasting glucose (mg/dl)	143.25 ± 11.20^a	137.75 ± 11.44^a	117.00 ± 16.37^b	140.50 ± 4.79^a
Insulin (ng/ml)	0.86 ± 0.32^a	0.97 ± 0.16^a	2.56 ± 0.80^b	1.00 ± 0.25^a
-Hydroxybutyrate (mmol/l)	0.43 ± 0.03	0.47 ± 0.02	0.37 ± 0.02	0.37 ± 0.02
NEFA (mmol/l)	0.51 ± 0.07^a	0.35 ± 0.04^b	0.57 ± 0.04^a,c	0.69 ± 0.01^c
Triglycerides (mmol/l)	1.21 ± 0.09^a	0.79 ± 0.22^b	0.98 ± 0.13^a	1.14 ± 0.10^a
Total cholesterol (mg/dl)	54.47 ± 5.44^a	36.46 ± 2.79^b	119.15 ± 5.79^c	110.40 ± 3.63^c
IGF-1 (ng/ml)	238.33 ± 7.93^a	130.00 ± 21.55^a	1112.50 ± 77.67^b	933.33 ± 124.39^c

Data is expressed as mean ± SD for = 5 in each group. Different superscripts denote significant difference at < 0.05.