Clinical Study
Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism
Table 1
Baseline characteristics of short-stature children with PPH accompanied by low GH levels.
| | Patient | CA (years) | BA (years) | GH peak (ng/mL) | FT3 (pmol/L) | FT4 (pmol/L) | TSH (mIU/L) | TPOAb (IU/mL) | TgAb (IU/mL) | IGF-1 (ng/mL) | PRL (g/L) | Pituitary height (mm) |
| | 1 M | 6.2 | 1.0 | 8.0 | 1.6 | 3.4 | >150 | 42.1 | 23.9 | 145.0 | 49.1 | 11.0 | | 2 M | 9.8 | 6.0 | 2.7 | 0.1 | 3.0 | >150 | >500 | >1300 | 78.0 | 32.2 | 14.0 | | 3 M | 11.2 | 8.0 | 5.1 | 1.2 | 4.3 | >150 | >500 | >1300 | 97.7 | 12.5 | 16.0 | | 4 M | 10.7 | 6.0 | 7.5 | 2.0 | 3.3 | >150 | 73.8 | >1300 | 68.61 | 52.6 | 18.0 | | 5 M | 10.8 | 7.0 | 2.6 | 2.6 | 4.3 | 75.0 | >500 | >1300 | 56.7 | 27.5 | 20.3 | | 6 M | 7.9 | 4.0 | 1.5 | 3.0 | 6.6 | >150 | >500 | 404.5 | 106.98 | 52.4 | 19.0 | | 7 M | 15.0 | 13.0 | 6.7 | 4.9 | 6.7 | 65.5 | >500 | >1300 | 147.42 | 28.5 | 14.0 | | 8 M | 15.8 | 10.0 | 8.0 | 1.0 | 1.2 | >150 | 627.3 | 36.9 | 148.3 | 41.5 | 14.0 | | 9 F | 5.0 | 3.0 | 7.1 | 0.2 | 3.6 | >150 | >500 | >1300 | 75.26 | 75.4 | 13.0 | | 10 F | 9.3 | 8.5 | 5.2 | 6.5 | 7.3 | 78.0 | >500 | 600.9 | 63.0 | 33.2 | 8.8 | | 11 F | 11.5 | 9.0 | 1.0 | 0.8 | 1.4 | >150 | >500 | >1300 | 123.0 | 41.4 | 9.0 |
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PPH: pituitary hyperplasia secondary to primary hypothyroidism; GH: growth hormone; M: male; F: female; CA: chronological age; BA: bone age; FT3: free triiodothyronine; FT4: free thyroxine; TSH: thyrotropin; TPOAb: thyroid peroxidase antibody; TgAb: thyroglobulin antibody; IGF-1: insulin-like growth factor-1; PRL: prolactin.
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