|
Author reference | Year | Type of survey | Population | Follow-up | Results |
|
Observational |
Bremner et al. [90] | 2012 | Cohort | 504 m 507 w mean age 58 y | — | FT4 levels are positively associated with Hb, hematocrit, and erythrocytes |
Schindhelm et al. [91] | 2013 | Cohort | 708 m and w mean age 68 y | — | FT4, but not TSH, is associated with Hb, hematocrit, and erythrocytes |
Lippi et al. [92] | 2014 | Retrospective | 221 m 829 w 58–73 y | — | TSH and FT4 are associated with RDW |
Shimizu et al. [93] | 2013 | Cross-sectional | 843 m 30–89 y | — | FT4 is inversely associated with anemia in nondrinkers |
Bashir et al. [94] | 2012 | Cross-sectional | 216 m 384 w 25–60 y | — | Alterations in hematological parameters in untreated subclinical and overt hypothyroid patients |
Lippi et al. [95] | 2008 | Retrospective | 331 m 615 w 21–87 y | — | No difference in the prevalence of folic acid and B12 deficiency between hypo- or hyperthyroid subjects |
Stella et al. [96] | 2007 | Cross-sectional | 119 m 160 w 60–85 y | — | Thyroid hormones are associated with vitamin B12 levels, but not with homocysteine |
|
Intervention |
Kazemi-Jahromi et al. [97] | 2010 | No RCT | 14 m 56 w 18–75 y | LT4 101.7 ± 38.3 µg/day 3 months | LT4 supplementation improves hypothyroidism and anemia |
Christ-Crain et al. [98] | 2003 | Double-blind RCT | 63 w 18–75 y | LT4 85.5 ± 4.3 µg/day 48 weeks | LT4 replacement significantly increases serum erythropoietin levels but did not affect Hb or hematocrit |
Ravanbod et al. [99] | 2013 | Double-blind RCT | 30 m 30 w mean age 32-33 y | Iron 65 mg/day, T4 50 µg/day or iron + T4 65 mg + 50 µg/day 3 months | Higher efficacy of a LT4 plus iron salts in hematological parameters |
Cinemre et al. [100] | 2009 | Double-blind RCT | 44 m 6 w 27–55 y | Iron 240 mg/day or Iron + LT4 240 mg + 75 µg/day 3 months | Higher efficacy of LT4 plus iron salts in iron status and blood count indices |
|