International Journal of Endocrinology / 2015 / Article / Tab 1

Review Article

Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

Table 1

Noninvasive fibrosis serum tests and scores to diagnose nonalcoholic steatohepatitis (NASH) and/or stage fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) [12].

TestVariablesNAFLD stage assessedCut-offAUROC

AST : ALT ratioALT and AST serum levelsF41NA

CK-18Cytokeratin 18 fragmentsNAFLD
NASH
Fibrosis (any degree)
NA0.77
0.65–0.83
0.68

FerritinSerum ferritinNASH/≥F2
≥F3
1.5 ULN
2.5 ULN
0.57
NA

NASH diagnosticCK-18 fragments, adiponectin, and resistinNASH0.430.70–0.85

NASH diagnostic panelGender, BMI, diabetes, triglycerides, and CK-18 (total levels and fragments)NASHNA0.81

NashTestAge, gender, weight, height, bilirubin, GGT, 2-macroglobulin, apolipoprotein A1, haptoglobin, AST, serum glucose, triglycerides, and cholesterolNo NASH
Borderline NASH
NASH
NANA
NA
0.69–0.83

NAFIC scoring systemFerritin ≥200 or ≥300 ng/mL (F or M) = 1
Serum fasting insulin ≥10 μU/mL = 1
Serum type IV collagen 7s ≥5.0 ng/mL = 2
NASH20.78–0.85

Modified NAFIC
scoring system
Ferritin ≥200 or ≥300 ng/mL (F or M) = 1
Serum fasting insulin ≥10 < 15 μU/mL = 1
Serum fasting insulin ≥15 = 2
Serum type IV collagen 7s ≥5.0 ng/mL = 2
NASH20.80

PIIINPTerminal peptide of procollagen III levelsNASH
≥F3
6.6 ng/mL (low cut-off)
11 ng/mL (high cut-off)
0.82
0.84

APRIAST, PLT≥F20.45 (low cut-off)
1.5 (high cut-off)
0.62–0.94

BARDBMI, AST/ALT ratio, and diabetes≥F3≥20.80

BARDIBMI, AST/ALT ratio, diabetes, and INR≥F3≥30.88

NAFLD fibrosis scoreAge, BMI, diabetes. AST, ALT, platelet count, and albumin≥F3−1.45 (low cut-off)
0.67 (high cut-off)
0.82–0.88

FIB-4Age, AST, ALT, and platelet count≥F31.3–1.92 (low cut-off)
3.25 (high cut-off)
0.87, 0.88

HepascoreAge, sex, bilirubin, GGT, α2-macroglobulin, and hyaluronic acid≥F2
≥F3
F4
0.44
0.37
0.7
0.73
0.81
0.9

ELF testHyaluronic acid (HA), PIIINP, and tissue inhibitor of metalloproteinase 1 (TIMP-1).≥F2
≥F3
F4
8.5–10.18
10.35 (9.33–10.51)
9.35–11.3
0.82
0.90
0.87

FibroTestHaptoglobin, α2-macroglobulin, apolipoprotein-A, bilirubin, and GGT≥F30.3 (low cut-off)
0.7 (high cut-off)
0.88

FibroMeterAge, weight, glucose, AST, ALT, PLT, and ferritin≥F2
≥F3
F4
F3: 0.61 (low cut-off)
0.71 (high cut-off)
0.94
0.93
0.9

ALT: alanine aminotransferase; AST: aspartate aminotransferase; AUROC: area under receiver operator characteristic curve; CK-18: cytokeratin 18; NA: not available; BMI: body mass index; GGT: -glutamyl transpeptidase; PLT: platelets; PIIINP: terminal peptide of procollagen III; APRI: aspartate aminotransferase to platelets ratio; INR: international normalized ratio; ELF: enhanced liver fibrosis; ULN: upper limit of normal.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.