Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation

Table 3

Absolute (Δ) changes in cortisol and ACTH levels at consecutive time points compared to baseline, stratified by remission status.

	Remission ()			Persistent CD ()			value
	Mean ± SD	Median	Range	Mean ± SD	Median	Range
Cortisol (μg/dL)
15′	0.81 ± 2.86	0.0	−0.1–11.1	8.71 ± 6.20	9.8	0.2–20.3	<0.001
30′	0.89 ± 3.06	0.1	−0.2–11.9	12.90 ± 7.10	13.8	0.3–22.3	<0.001
60′	0.60 ± 2.01	0.0	−0.2–7.8	14.50 ± 7.80	14.0	0.3–24.8	<0.001
90′	0.41 ± 1.32	0.0	−0.2–5.1	13.14 ± 8.55	13.7	−0.1–28.7	<0.001
120′	0.28 ± 1.07	0.0	−0.1–4.1	10.97 ± 8.77	9.2	−0.8–32.6	<0.001
ACTH (pg/mL)
15′	5.02 ± 7.17	2.0	0.0–27.0	151.31 ± 292.89	55.0	1.0–1093.0	<0.001
30′	3.19 ± 4.42	1.0	−0.5–16.0	128.15 ± 227.38	56.0	3.0–858.0	<0.001
60′	1.16 ± 2.08	0.5	−1.0–5.0	66.85 ± 120.70	33.0	1.0–460.0	<0.001
90′	0.23 ± 1.41	0.0	−2.0–4.0	50.69 ± 106.12	25.0	2.0–399.0	<0.001
120′	−0.25 ± 1.51	0.0	−3.0–3.0	38.39 ± 96.01	9.0	−2.0–353.0	0.002