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International Journal of Endocrinology
Volume 2015, Article ID 401851, 13 pages
Research Article

Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients

Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA

Received 26 March 2015; Accepted 23 August 2015

Academic Editor: Sabrina Corbetta

Copyright © 2015 Vinodh Kumar Radhakrishnan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Since our breast cancer samples from Vietnamese patients is limited (n=48), we provided Supplementary Figure 1 which represents the results of the IGF-II rs680 C/T allele count from the 1000 Human Genome Ensemble ( from different ethnic groups.

Supplementary Figure 2 represents unpublished data from our own IGF-II rs680 C/T allele count from paired breast cancer samples from Caucasian American (n=32), South Korean (n=42) and African American (n=36).

Please note that when we compared the allele count for the rs680 SNP in our paired breast sample analysis from Caucasian American, South Korean and African American (Supplementary figure 2) to the 1000 Human Genome Ensemble for the same populations ( it shows that the published percentage allele count is almost identical to ours (Supplementary Figure 1). Thus, the allele count of the IGF-II rs680 in our sample size is comparable to the allele count in the reference populations where the samples range from 181-379. This is important, because it strengthen the significance of our results even though our sample size is limited.

  1. Supplementary Material