Research Article
Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
Table 2
Association between MET SNPs (rs1621 and rs6566) and thyroid tumors as stratified by the gender.
| | MET | Male | Female | | PTC () | NG () | NC () | value | PTC () | NG () | NC () | value |
| | rs1621 | | | | | | | | | | AA | 165 (79.3%) | 113 (82.5%) | 175 (79.5%) | 0.902 | 491 (75.7%) | 335 (80.1%) | 549 (81.2%) | 0.037 | | AG | 41 (19.7%) | 22 (16.1%) | 42 (19.1%) | 152 (23.4%) | 76 (18.2%) | 116 (17.2%) | | GG | 2 (1%) | 2 (1.5%) | 3 (1.4%) | 6 (0.9%) | 7 (1.7%) | 11 (1.6%) | | A | 371 (89.2%) | 248 (90.5%) | 392 (89.1%) | 0.811 | 1134 (87.4%) | 746 (89.2%) | 1214 (89.8%) | 0.125 | | G | 45 (10.8%) | 26 (9.5%) | 48 (10.9%) | 164 (12.6%) | 90 (10.8%) | 138 (10.2%) | | rs6566 | | | | | | | | | | AA | 40 (19.1%) | 38 (27.5%) | 47 (21.7%) | 0.364 | 138 (21.2%) | 93 (22.5%) | 167 (24.9%) | 0.261 | | AG | 112 (53.6%) | 65 (47.1%) | 119 (54.8%) | 320 (49.2%) | 207 (50%) | 339 (50.5%) | | GG | 57 (27.3%) | 35 (25.4%) | 51 (23.5%) | 193 (29.6%) | 114 (27.5%) | 165 (24.6%) | | A | 192 (45.9%) | 141 (51.1%) | 213 (49.1%) | 0.574 | 596 (45.8%) | 393 (47.5%) | 673 (50.1%) | 0.077 | | G | 226 (54.1%) | 135 (48.9%) | 221 (50.9%) | 706 (54.2%) | 435 (52.5%) | 669 (49.9%) |
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PTC: papillary thyroid cancer; NG: nodular goiter; NC: normal control; versus the genotype AG in rs1621 in the NC group.
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