Research Article
The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis
Table 1
Comparison of clinicopathologic characteristics between WLPTC and classic PTC.
| | Characteristic | Classic PTC () | WLPTC () | value |
| | Mean age (years) | 45 (22–73) | 46 (18–77) | 0.595 | | Age | | | 0.729 | | <45 | 94 (47%) | 17 (43%) | | | ≥45 | 106 (53%) | 23 (58%) | | | Sex | | | 0.374 | | Female | 161 (81%) | 35 (88%) | | | Male | 39 (20%) | 5 (13%) | | | Multifocality | | | 0.385 | | Unifocal | 108 (54%) | 25 (63%) | | | Multifocal | 92 (46%) | 15 (38%) | | | Surgery type | | | 0.088 | | Lobectomy | 63 (32%) | 7 (18%) | | | Total thyroidectomy | 137 (69%) | 33 (83%) | | | Median tumor size (cm) | 0.7 (0.2–4.5) | 1.0 (0.4–2.2) | 0.043 | | pT stage | | | 0.134 | | pT1 | 123 (62%) | 30 (75%) | | | pT2 | 2 (1%) | 1 (3%) | | | pT3 | 75 (38%) | 9 (23%) | | | Extrathyroidal extension | | | 0.073 | | Absent | 125 (63%) | 31 (78%) | | | Present | 75 (38%) | 9 (23%) | | | pN stage | | | 0.730 | | pN0 | 102 (51%) | 22 (55%) | | | pN1 | 98 (49%) | 18 (45%) | | | Hashimoto’s thyroiditis | | | <0.001 | | Absent | 147 (74%) | 8 (20%) | | | Present | 53 (27%) | 32 (80%) | | | Preoperative diagnosis | | | 0.697 | | Atypia of undetermined significance | 7 (4%) | 2 (5%) | | | Suspicious for PTC | 45 (23%) | 7 (18%) | | | PTC | 148 (74%) | 31 (78%) | | | BRAF mutation | | | 0.015 | | Absent | 33 (17%) | 14 (35%) | | | Present | 167 (84%) | 26 (65%) | |
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PTC, papillary thyroid carcinoma; WLPTC, Warthin-like variant of papillary thyroid carcinoma.
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