The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis

Table 4

Comparison of clinicopathologic characteristics between WLPTC and classic PTC microcarcinomas (≤1 cm).

Characteristics of microcarcinomas	Classic PTC ()	WLPTC ()	value
Mean age (years)	45 (23–73)	44 (18–63)	0.871
Age			1.000
<45	75 (47%)	12 (48%)
≥45	86 (53%)	13 (52%)
Sex			0.263
Female	129 (80%)	23 (92%)
Male	32 (20%)	2 (8%)
Multifocality			0.196
Unifocal	93 (58%)	18 (72%)
Multifocal	68 (42%)	7 (28%)
Surgery type			0.378
Lobectomy	62 (39%)	7 (28%)
Total thyroidectomy	99 (62%)	18 (72%)
Median tumor size (cm)	0.6 (0.2–1.0)	0.7 (0.4–1.0)	0.001
pT stage			0.476
pT1	116 (72%)	20 (80%)
pT2	0 (0%)	0 (0%)
pT3	45 (28%)	5 (20%)
Extrathyroidal extension			0.476
Absent	116 (72%)	20 (80%)
Present	45 (28%)	5 (20%)
pN stage			0.385
pN0	92 (57%)	17 (68%)
pN1	69 (43%)	8 (32%)
Hashimoto’s thyroiditis			<0.001
Absent	121 (75%)	5 (20%)
Present	40 (25%)	20 (80%)
Preoperative diagnosis			0.521
Atypia of undetermined significance	6 (4%)	2 (8%)
Suspicious for PTC	40 (25%)	6 (24%)
PTC	114 (71%)	17 (68%)
BRAF mutation			0.103
Absent	28 (17%)	8 (32%)
Present	133 (83%)	17 (68%)

PTC, papillary thyroid carcinoma; WLPTC, Warthin-like variant of papillary thyroid carcinoma.