International Journal of Endocrinology

Research Article

Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression

Table 2

Associations between labour associated inflammatory genes (PTGS2, BMP2, NAMPT, and CXCL2) and steroid receptor genes (PGR, ESR1, and NR3C1) allele hypermethylation and the percentage of gene alleles that were hypermethylated in ACE, AGTR1, ATP6AP2, CTSD, and KLK1 in amnion and decidua.


	ACE1	AGTR1	ATP6AP2	CTSD	KLK1

Amnion
PTGS2	r = 0.85	r = 0.81	r = 0.50	r = 0.60	ns
PTGS2	P < 0.001	P < 0.001	P = 0.036	P < 0.01	ns
BMP2	r = 0.83	r = 0.90	r = 0.57	r = 0.82	ns
BMP2	P < 0.001	P < 0.001	P = 0.017	P < 0.001	ns
NAMPT	r = 0.71	r = 0.72	ns	r = 0.68	ns
NAMPT	P < 0.001	P < 0.001	ns	P = 0.001	ns
CXCL2	r = 0.94	r = 0.80	r = 0.69	r = 0.56	ns
CXCL2	P < 0.001	P < 0.001	P = 0.002	P = 0.013	ns
NR3C1	r = 0.72	r = 0.78	r = 0.49	r = 0.49	ns
NR3C1	P < 0.001	P < 0.001	P = 0.035	P = 0.03	ns
PGR	r = 0.85	r = 0.83	r = 0.53	r = 0.71	ns
PGR	P < 0.001	P < 0.001	P = 0.02	P < 0.001	ns
ESR1	r = 0.87	r = 0.77	r = 0.71	r = 0.49	ns
ESR1	P < 0.001	P < 0.001	P = 0.001	P = 0.038	ns

Decidua
PTGS2	r = 0.75	r = 0.72	ns	r = 0.86	ns
PTGS2	P = 0.001	P = 0.003	ns	P < 0.001	ns
BMP2	r = 0.90	r = 0.90	r = 0.62	r = 0.84	ns
BMP2	P < 0.001	P < 0.001	P = 0.033	P < 0.001	ns
NAMPT	r = 0.55	ns	ns	r = 0.83	ns
NAMPT	P = 0.04	ns	ns	P < 0.001	ns
CXCL2	r = 0.88	r = 0.82	r = 0.78	r = 0.77	ns
CXCL2	P < 0.001	P < 0.001	P = 0.001	P = 0.001	ns
NR3C1	ns	ns	ns	ns	ns
PGR	r = 0.93	r = 0.94	r = 0.71	r = 0.87	ns
PGR	P < 0.001	P < 0.001	P = 0.005	P < 0.001	ns
ESR1	r = 0.72	r = 0.80	ns	r = 0.83	ns
ESR1	P = 0.003	P < 0.001	ns	P < 0.001	ns

ns = not significant.