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International Journal of Endocrinology
Volume 2015 (2015), Article ID 545068, 6 pages
http://dx.doi.org/10.1155/2015/545068
Research Article

Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients

1Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic
2Clinic of Internal Medicine, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic
3Department of Sports and Exercise Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic
4Department of Clinical Biochemistry and Immunogenetics, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic
5Department of Clinical Biochemistry, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic
6Department of Respiratory Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic
7Department of Transfusion Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic
8Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic

Received 2 December 2014; Accepted 23 April 2015

Academic Editor: Alexander Schreiber

Copyright © 2015 Dagmar Horáková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.