|
| Author, Date | Population | Findings |
|
|
Xiang et al., 2007 [29] | 22 newly diagnosed type 1 DM
28 healthy subjects | Plasma OPG levels are elevated in newly diagnosed type 1 DM |
| Singh et al., 2010 [30] | 35 type 1 DM
25 sex, age, ethnicity matched controls | Serum OPG levels were significantly lower in patients with type 1 DM compared to normal controls. |
| Rasmussen et al., 2006 [31] | 199 type 1 DM without diabetic nephropathy
192 type 1 DM with diabetic nephropathy | OPG associated with cardiovascular disease and glycaemic control |
| Grauslund et al., 2010 [32] | Population-based Fyn County Denmark
200 type 1 DM long diabetes duration | OPG associated with higher risk of nephropathy |
| Wang et al., 2013 [33] | 80 type 1 DM
30 controls | OPG associated with the presence and severity of nephropathy |
| Nybo et al., 2010 [34] | 200 type 1 DM
305 type 2 DM | OPG correlated with diabetic neuropathy |
| Avignon et al., 2007 [37] | 465 diabetic patients with one additional risk factor | OPG is associated with silent myocardial ischemia |
| Gordin et al., 2013 [35] | 1,939 adults (population FinnDiane)
Finnish Diabetic Nephropathy Study | OPG predicted an incident cardiovascular event and peripheral vascular disease
Follow-up 10.4 years |
| Jorsal et al., 2008 [36] | 397 type 1 DM overt nephropathy
176 type 1 DM with persistent normoalbuminuria | OPG associated with mortality and renal deterioration
Follow-up 11.3 years. Prospective observational study |
|
