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International Journal of Endocrinology
Volume 2015, Article ID 708272, 9 pages
http://dx.doi.org/10.1155/2015/708272
Research Article

Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography

Yan Ling, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Bingjie Wu, Shanshan Wang, Xiaojing Liu, and Xin Gao

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China

Received 6 July 2015; Revised 22 November 2015; Accepted 25 November 2015

Academic Editor: Constantinos Pantos

Copyright © 2015 Yan Ling et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. J. Kahaly and W. H. Dillmann, “Thyroid hormone action in the heart,” Endocrine Reviews, vol. 26, no. 5, pp. 704–728, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Biondi, E. A. Palmieri, G. Lombardi, and S. Fazio, “Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 968–974, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. A. R. Cappola and P. W. Ladenson, “Hypothyroidism and atherosclerosis,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 6, pp. 2438–2444, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Klein and K. Ojamaa, “Thyroid hormone and the cardiovascular system,” The New England Journal of Medicine, vol. 344, no. 7, pp. 501–509, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Rodondi, W. P. J. den Elzen, D. C. Bauer et al., “Subclinical hypothyroidism and the risk of coronary heart disease and mortality,” The Journal of the American Medical Association, vol. 304, no. 12, pp. 1365–1374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. T.-H. Collet, J. Gussekloo, D. C. Bauer et al., “Subclinical hyperthyroidism and the risk of coronary heart disease and mortality,” Archives of Internal Medicine, vol. 172, no. 10, pp. 799–809, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. K. A. Hyland, A. M. Arnold, J. S. Lee, and A. R. Cappola, “Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study,” The Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 2, pp. 533–540, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. R. Cappola, L. P. Fried, A. M. Arnold et al., “Thyroid status, cardiovascular risk, and mortality in older adults,” The Journal of the American Medical Association, vol. 295, no. 9, pp. 1033–1041, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. S. Kim, J. A. Shin, J. Y. Shin et al., “Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjects,” Thyroid, vol. 22, no. 9, pp. 870–876, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Ertaş, H. Kaya, and M. S. Soydinç, “Low serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational study,” Anadolu Kardiyoloji Dergisi, vol. 12, no. 7, pp. 591–596, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Yang, J. Zou, M. Zhang et al., “The relationship between thyroid stimulating hormone within the reference range and coronary artery disease: impact of age,” Endocrine Journal, vol. 60, no. 6, pp. 773–779, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. C.-H. Jung, E.-J. Rhee, H.-S. Shin et al., “Higher serum free thyroxine levels are associated with coronary artery disease,” Endocrine Journal, vol. 55, no. 5, pp. 819–826, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. H. Yun, M. H. Jeong, S. K. Oh et al., “Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients,” International Journal of Cardiology, vol. 122, no. 1, pp. 56–60, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. B. O. Åsvold, T. Bjøro, C. Platou, and L. J. Vatten, “Thyroid function and the risk of coronary heart disease: 12-year follow-up of the HUNT Study in Norway,” Clinical Endocrinology, vol. 77, no. 6, pp. 911–917, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. G. Gensini, “A more meaningful scoring system for determining the severity of coronary heart disease,” The American Journal of Cardiology, vol. 51, no. 3, p. 606, 1983. View at Publisher · View at Google Scholar · View at Scopus
  16. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  17. I. Klein and S. Danzi, “Thyroid disease and the heart,” Circulation, vol. 116, no. 15, pp. 1725–1735, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. L. H. Duntas, “Thyroid disease and lipids,” Thyroid, vol. 12, no. 4, pp. 287–293, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Razvi, L. Ingoe, G. Keeka, C. Oates, C. McMillan, and J. U. Weaver, “The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 5, pp. 1715–1723, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Caraccio, E. Ferrannini, and F. Monzani, “Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study,” The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 4, pp. 1533–1538, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Monzani, N. Caraccio, M. Kozàkowà et al., “Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study,” The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 5, pp. 2099–2106, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Tian, Y. Song, M. Xing et al., “A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway,” Hepatology, vol. 52, no. 4, pp. 1401–1409, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Tognini, A. Polini, G. Pasqualetti et al., “Age and gender substantially influence the relationship between thyroid status and the lipoprotein profile: results from a large cross-sectional study,” Thyroid, vol. 22, no. 11, pp. 1096–1103, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Wang, Y. Tan, C. Wang et al., “Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones,” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 8, pp. 2724–2731, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Xu, X. Yang, W. Liu et al., “Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design,” Nutrition and Metabolism, vol. 9, article 44, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Meier, P. Trittibach, M. Guglielmetti, J.-J. Staub, and B. Müller, “Serum thyroid stimulating hormone in assessment of severity of tissue hypothyroidism in patients with overt primary thyroid failure: cross sectional survey,” British Medical Journal, vol. 326, no. 7384, pp. 311–312, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. M. D. Gammage, J. V. Parle, R. L. Holder et al., “Association between serum free thyroxine concentration and atrial fibrillation,” Archives of Internal Medicine, vol. 167, no. 9, pp. 928–934, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J. G. Hollowell, N. W. Staehling, W. D. Flanders et al., “Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III),” The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 2, pp. 489–499, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. R. C. Marchiori, L. A. Pereira, A. A. Naujorks et al., “Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment,” BMC Endocrine Disorders, vol. 15, article 32, 2015. View at Publisher · View at Google Scholar
  30. I. Kowalska, J. Borawski, A. Nikołajuk et al., “Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy,” Endocrine, vol. 40, no. 1, pp. 95–101, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Razvi, L. Ingoe, G. Keeka, C. Oates, C. McMillan, and J. U. Weaver, “The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 5, pp. 1715–1723, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. A. del Busto-Mesa, J. O. Cabrera-Rego, L. Carrero-Fernández, C. V. Hernández-Roca, J. L. González-Valdés, and J. E. de la Rosa-Pazos, “Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism,” Endocrinología y Nutrición (English Edition), vol. 62, no. 6, pp. 270–276, 2015. View at Publisher · View at Google Scholar
  33. T. Nagasaki, M. Inaba, Y. Henmi et al., “Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy,” European Journal of Endocrinology, vol. 150, no. 2, pp. 125–131, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. F. A. Oner, S. Yurdakul, E. Oner, A. K. Uzum, and M. Erguney, “Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism,” Endocrine, vol. 40, no. 2, pp. 280–284, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Tamer, M. Mert, I. Tamer, B. Mesci, D. Kilic, and S. Arik, “Effects of thyroid autoimmunity on abdominal obesity and hyperlipidaemia,” Endokrynologia Polska, vol. 62, no. 5, pp. 421–428, 2011. View at Google Scholar · View at Scopus
  36. G.-D. Xiang, Y.-S. He, L.-S. Zhao, J. Hou, L. Yue, and H.-J. Xiang, “Impairment of endothelium-dependent arterial dilation in Hashimoto's thyroiditis patients with euthyroidism,” Clinical Endocrinology, vol. 64, no. 6, pp. 698–702, 2006. View at Publisher · View at Google Scholar · View at Scopus