Cytotoxic T Lymphocyte-Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Diseases: An Updated Systematic Review and Cumulative Meta-Analysis

Table 1

Characteristics of new studies included in the meta-analysis.

Study	Year	Country	Ethnicity	Gene	Disease	Cases			Controls
						AA	AG	GG	AA	AG	GG
Wang et al. [24]	2001	China	Asian	A49G	GD	37	47	3	27	26	7
Zhou et al. [25]	2003	China	Asian	A49G	GD	32	14	4	5	5	10
Zhang et al. [8]	2006	China	Asian	A49G	GD	37	18	1	26	25	29
Yao et al. [26]	2006	China	Asian	A49G	GD	58	53	9	55	57	11
Yu et al. [32]	2006	China	Asian	A49G	GD	51	36	13	26	46	28
Wang et al. [9]	2007	China	Asian	A49G	GD	124	69	15	46	60	20
Yu et al. [27]	2008	China	Asian	A49G	GD	67	45	13	13	27	29
Chong et al. [10]	2008	China	Asian	A49G	GD	97	73	7	16	67	103
Cury et al. [11]	2008	Brazil	American	A49G	GD	15	58	43	6	64	47
Bicek et al. [12]	2009	Slovenia	Caucasian	A49G	GD	17	73	33	14	52	24
Kimura et al. [13]	2009	Japan	Asian	A49G	GD	210	143	62	10	42	32
Wang et al. [28]	2010	China	Asian	A49G	GD	38	47	5	16	20	14
Guo et al. [29]	2010	China	Asian	A49G	GD	26	52	24	12	47	41
Zhao et al. [14]	2010	China	Asian	A49G	GD	1030	730	104	295	358	142
Pastuszak-Lewandoska et al. [15]	2012	Poland	Caucasian	A49G	GD	7	6	1	97	77	18
Veeramuthumari et al. [16]	2011	India	Caucasian	A49G	GD	32	37	11	71	56	24
Kimkong et al. [17]	2011	Thailand	Asian	A49G	GD	61	49	22	54	73	26
Farra et al. [18]	2012	Lebanon	Caucasian	A49G	GD	6	18	31	7	32	39
Pastuszak-Lewandoska et al. [19]	2013	Poland	Caucasian	A49G	GD	12	9	3	945	823	156
Pastuszak-Lewandoska et al. [15]	2012	Poland	Caucasian	A49G	HT	6	19	3	5	5	10
Zhou et al. [25]	2003	China	Asian	A49G	HT	24	14	8	46	60	20
Yu et al. [27]	2008	China	Asian	A49G	HT	41	34	5	15	64	22
Dallos et al. [20]	2008	Slovakia	Caucasian	A49G	HT	13	34	16	13	27	29
Kucharska et al. [21]	2009	Poland	Caucasian	A49G	HT	31	40	29	16	67	103
Bicek et al. [12]	2009	Slovenia	Caucasian	A49G	HT	15	46	51	6	64	47
Sahin et al. [22]	2009	Turk	Caucasian	A49G	HT	21	91	85	17	54	49
Farra et al. [18]	2012	Lebanon	Caucasian	A49G	HT	6	31	36	16	20	14
Ying et al. [30]	2012	China	Asian	A49G	HT	46	53	51	31	91	108
Pastuszak-Lewandoska et al. [19]	2013	Poland	Caucasian	A49G	HT	14	8	3	7	48	43
Wang et al. [9]	2007	China	Asian	CT60	GD	138	46	5	30	61	26
Chong et al. [10]	2008	China	Asian	CT60	GD	125	48	4	735	516	84
Tsai et al. [23]	2008	China	Asian	CT60	GD	136	48	5	125	58	9
Bicek et al. [12]	2009	Slovenia	Caucasian	CT60	GD	50	57	16	88	51	12
Kimura et al. [13]	2009	Japan	Asian	CT60	GD	267	127	21	82	59	12
Kimkong et al. [17]	2011	Thailand	Asian	CT60	GD	78	46	8	372	216	32
Qu et al. [31]	2014	China	Asian	CT60	GD	1989	487	114	1550	474	136
Dallos et al. [20]	2008	Slovakia	Caucasian	CT60	HT	31	28	4	20	50	25
Bicek et al. [12]	2009	Slovenia	Caucasian	CT60	HT	37	52	23	30	61	26