Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D

Figure 8

Effect of apigenin-7-O-glucoside and luteolin-7-O-glucoside on phospholipase D activity and glucose metabolism stimulation by insulin in the isolated hepatocytes. Apigenin-7-O-glucoside—AP7Glu, luteolin-7-O-glucoside—LU7Glu. Flavones added to the culture media prior to (a, b, c) and after (d, e, f) insulin as described in the Methods. (a, d) Phospholipase D activity, (b, e) uptake of 2-D-[³H]glucose, (c, f) incorporation of D-[U ¹⁴C]glucose into glycogen. , insulin versus control.