International Journal of Endocrinology / 2015 / Article / Tab 3

Research Article

Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy

Table 3

Characteristics of patients and cellular localization of molecules involved in glucose metabolism.

Patient 3Patient 4Patient 5Patient 6Patient 7

Variable
Age (years)11.28.076.26.4811.2
Age of onset (years)1.5251.53
Wheelchair 
dependency
NoNoNoNoNo
Exon deleted484545, 47, 484445, 48
Dys C+ − −− − −+ + ++ − −+ + −
Dys N+ − −+ − −+ + −+ − −+ − −
Insulin (U/mL)32.16.427.510.0938.9
Glucose (mg/dL) 90.688.4 102.3100.5 84.5
HOMA-IR9.81.417.42.518.1

A subjective value was assigned (normal + + +, decreased + + −, considerably decreased + − −, and absent − − −) to describe staining indicating the presence of dystrophin. ND: not detected by multiplex PCR; GLUT4: glucose transporter 4; Dys-C: dystrophin C-terminus; Dys-N: dystrophin N-terminus; HOMA-IR: homeostasis model assessment-insulin resistance.

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