Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women
Table 4
The partial coefficient correlation of PCOS, leptin, and sOB-R in PCOS subjects.
Variable
PCOS
Leptin ng/mL
Soluble leptin receptor
Coefficient
Coefficient
Coefficient
Testosterone (F)
0.745
<0.0001
0.416
0.085
−0.148
0.557
DHEAS
0.411
0.0002
0.406
0.094
−0.082
0.744
Progesterone
0.020
0.865
0.154
0.494
0.078
0.494
Estradiol
0.140
0.204
0.124
0.554
−0.010
0.926
Insulin
0.155
0.176
0.282
0.203
−0.228
0.064
SHBG
−0.171
0.445
−0.367
0.235
0.198
0.081
Glucose
0.011
0.892
0.199
0.086
0.044
0.703
FAI
0.685
0.003
0.353
0.150
0.193
0.055
Prolactin
0.081
0.480
0.180
0.115
0.034
0.765
TSH
0.016
0.893
0.131
0.561
−0.234
0.039
Free T4
0.092
0.577
−0.051
0.757
−0.028
0.872
Irregular cycles (yes)
0.580
0.000
0.143
0.212
−0.255
0.086
PCOS (yes)
—
—
0.282
0.012
−0.349
0.001
Leptin
0.277
0.014
—
—
−0.361
0.001
sOB-R
−0.313
0.005
−0.718
0.001
—
—
HOMA-IR
0.254
0.247
0.323
0.124
−0.353
0.074
Data were analyzed by partial coefficient correlation after adjustment for BMI. Correlation is significant at two-tailed value at <0.05. Body mass index (BMI); free androgen index (FAI); thyroxin (T4); dehydroepiandrosterone sulfate (DHEAS); thyroid-stimulating hormone (TSH); sex hormone binding globulin (SHBG); soluble leptin receptor (sOB-R); free leptin index (FLI); free testosterone (F); and insulin resistance (HOMA-IR).
