International Journal of Endocrinology / 2015 / Article / Tab 1

Clinical Study

Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature

Table 1

Clinical course of laboratory findings.

Week ActionFT3FT4TSHALTASTTBDBPTWBCGranulocytes
Normal range3.23–7.22 pmol/L10.3–24.45 pmol/L0.4–4.0 mIU/L5–40 U/L8–40 U/L0–21 µmol/L1–5 µmol/L10–13.5 s4.0–10.0 × 109/L2.0–7.0 × 109/L

−4Diagnosis MMI 20 mg/day started12.7856.720.00130211274.22.2
0MMI stopped5.6137.10.0018930385299171.10
1 4.1530.80.0093522390224162.30.5
2 5.8622.30.00930221581225.93.1
3 131I treatment with 8 mCi9.4232.80.00937229542139.16.6
5 322120125.12.9
154.413.60.00922231684.82.6
274.410.62.118181574.92.3

FT3: free triiodothyronine; FT4: free thyroxine; TSH: thyroid stimulating hormone; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TB: total bilirubin; DB: direct bilirubin; PT: prothrombin time; WBC: white blood count; “—” means no such examinations were done.

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