Mechanisms of Normalisation of Bone Metabolism during Recovery from Hyperthyroidism: Potential Role for Sclerostin and Parathyroid Hormone

Table 2

Comparison of distributions of selected parameters before and during treatment ( value of Wilcoxon’s matched pairs test).

	Before treatment	During treatment	value	Reference range
	(mean ± SD)	(mean ± SD)
Sclerostin (pmol/L)	43.7 ± 29.2	28.1 ± 18.4	0.000001	10.9–28.7
Osteocalcin (ng/mL)	35.6 ± 22.0	27.0 ± 14.3	0.00004	15–46
CTX (ng/dL)	0.49 ± 0.35	0.35 ± 0.23	0.0016	0.13–0.71
Calcium (mmol/L)	2.47 ± 0.10	2.49 ± 0.38	0.061	2.2–2.55
PTH (pg/mL)	29.3 ± 14.9	39.8 ± 19.8	0.0005	15–65
FT3 (pg/mL)	10.16 ± 5.36	3.17 ± 1.03	0.000001	2.6–4.4
FT4 (pg/mL)	4.03 ± 2.33	1.10 ± 0.82	0.0006	0.93–1.7
TSH (µIU/mL)	0.01 ± 0.01	1.27 ± 2.56	0.0001	0.27–4.2