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International Journal of Endocrinology
Volume 2015, Article ID 949620, 7 pages
http://dx.doi.org/10.1155/2015/949620
Research Article

Gender-Specific Differences in Clinical Profile and Biochemical Parameters in Patients with Cushing’s Disease: A Single Center Experience

1Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
2Division of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China

Received 14 February 2015; Revised 23 April 2015; Accepted 26 April 2015

Academic Editor: Carlo Cappelli

Copyright © 2015 Xiaoxia Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. E. Boggan, J. B. Tyrrell, and C. B. Wilson, “Transsphenoidal microsurgical management of Cushing's disease. Report of 100 cases,” Journal of Neurosurgery, vol. 59, no. 2, pp. 195–200, 1983. View at Publisher · View at Google Scholar · View at Scopus
  2. T. A. Howlett, P. L. Drury, L. Perry, I. Doniach, L. H. Rees, and G. M. Besser, “Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production,” Clinical Endocrinology, vol. 24, no. 6, pp. 699–713, 1986. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Newell-Price, P. Trainer, M. Besser, and A. Grossman, “The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states,” Endocrine Reviews, vol. 19, no. 5, pp. 647–672, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Boscaro, L. Barzon, F. Fallo, and N. Sonino, “Cushing's syndrome,” The Lancet, vol. 357, no. 9258, pp. 783–791, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. C. G. Patil, S. P. Lad, G. R. Harsh, E. R. Laws Jr., and M. Boakye, “National trends, complications, and outcomes following transsphenoidal surgery for Cushing's disease from 1993 to 2002,” Neurosurgical Focus, vol. 23, no. 3, article E7, 2007. View at Google Scholar · View at Scopus
  6. F. P. Giraldi, M. Moro, and F. Cavagnini, “Gender-related differences in the presentation and course of Cushing's disease,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1554–1558, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Huan, Y. Qu, and Z. Ren, “Gender differences in presentation and outcome of patients with Cushing's disease in Han Chinese,” Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3439–3446, 2014. View at Google Scholar
  8. M. Zilio, M. Barbot, F. Ceccato et al., “Diagnosis and complications of Cushing's disease: gender-related differences,” Clinical Endocrinology, vol. 80, no. 3, pp. 403–410, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. A. G. Ambrogio, M. De Martin, P. Ascoli, F. Cavagnini, and F. P. Giraldi, “Gender-dependent changes in haematological parameters in patients with Cushing's disease before and after remission,” European Journal of Endocrinology, vol. 170, no. 3, pp. 393–400, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Gilbert and E. M. Lim, “The diagnosis of Cushing's syndrome: an endocrine society clinical practice guideline,” The Clinical Biochemist Reviews, vol. 29, no. 3, pp. 103–106, 2008. View at Google Scholar
  11. A. Colao, C. De Block, M. S. Gaztambide, S. Kumar, J. Seufert, and F. F. Casanueva, “Managing hyperglycemia in patients with Cushing's disease treated with pasireotide: medical expert recommendations,” Pituitary, vol. 17, no. 2, pp. 180–186, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Arnaldi, A. Angeli, A. B. Atkinson et al., “Diagnosis and complications of Cushing's syndrome: a consensus statement,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 5593–5602, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. G. C. Farrell, S. Chitturi, G. K. K. Lau, and J. D. Sollano, “Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary,” Journal of Gastroenterology and Hepatology, vol. 22, no. 6, pp. 775–777, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. H. L. Storr, A. M. Isidori, J. P. Monson, G. M. Besser, A. B. Grossman, and M. O. Savage, “Prepubertal Cushing's disease is more common in males, but there is no increase in severity at diagnosis,” The Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 8, pp. 3818–3820, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Magiakou, G. Mastorakos, E. H. Oldfield et al., “Cushing's syndrome in children and adolescents: presentation, diagnosis, and therapy,” The New England Journal of Medicine, vol. 331, no. 10, pp. 629–636, 1994. View at Publisher · View at Google Scholar · View at Scopus
  16. O. Wessely, E.-M. Deiner, H. Beug, and M. Von Lindern, “The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors,” The EMBO Journal, vol. 16, no. 2, pp. 267–280, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Cushing, “The basophil adenomas of the pituitary body and their clinical manifestations,” Johns Hopkins Bulletin, vol. 50, pp. 137–195, 1932. View at Google Scholar
  18. A. D. Coviello, B. Kaplan, K. M. Lakshman, T. Chen, A. B. Singh, and S. Bhasin, “Effects of graded doses of testosterone on erythropoiesis in healthy young and older men,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 3, pp. 914–919, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Bachman, T. G. Travison, S. Basaria et al., “Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point,” Journals of Gerontology—Series A Biological Sciences and Medical Sciences, vol. 69, no. 6, pp. 725–735, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. D. J. Torpy, N. Mullen, I. Ilias, and L. K. Nieman, “Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases,” Annals of the New York Academy of Sciences, vol. 970, pp. 134–144, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Ulick, J. Z. Wang, J. D. Blumenfeld, and T. G. Pickering, “Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 74, no. 5, pp. 963–967, 1992. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Mancini, B. Kola, F. Mantero, M. Boscaro, and G. Arnaldi, “High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines,” Clinical Endocrinology, vol. 61, no. 6, pp. 768–777, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Valassi, A. Santos, M. Yaneva et al., “The European Registry on Cushing's syndrome: 2-Year experience. Baseline demographic and clinical characteristics,” European Journal of Endocrinology, vol. 165, no. 3, pp. 383–392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. M. Stewart, B. R. Walker, G. Holder, D. O'Halloran, and C. H. L. Shackleton, “11β-hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome,” The Journal of Clinical Endocrinology & Metabolism, vol. 80, no. 12, pp. 3617–3620, 1995. View at Google Scholar · View at Scopus
  25. R. Giordano, A. Picu, E. Marinazzo et al., “Metabolic and cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during active disease and 1 year after remission,” Clinical Endocrinology (Oxf), vol. 75, no. 3, pp. 354–360, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. A. Magiakou, G. Mastorakos, K. Zachman, and G. P. Chrousos, “Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 6, pp. 1734–1738, 1997. View at Google Scholar · View at Scopus
  27. M. B. Lodish, N. Sinaii, N. Patronas et al., “Blood pressure in pediatric patients with Cushing syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 6, pp. 2002–2008, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. D. C. Kem, M. H. Weinberger, C. Gomez-Sanchez, J. R. Higgins, and N. J. Kramer, “The role of ACTH in the episodic release of aldosterone in patients with idiopathic adrenal hyperplasia, hypertension, and hyperaldosteronism,” Journal of Laboratory and Clinical Medicine, vol. 88, no. 2, pp. 261–270, 1976. View at Google Scholar · View at Scopus
  29. T. Saruta, H. Suzuki, M. Handa, Y. Igarashi, K. Kondo, and S. Senba, “Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome,” The Journal of Clinical Endocrinology & Metabolism, vol. 62, no. 2, pp. 275–279, 1986. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Mazziotti, C. Gazzaruso, and A. Giustina, “Diabetes in Cushing syndrome: basic and clinical aspects,” Trends in Endocrinology and Metabolism, vol. 22, no. 12, pp. 499–506, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. X. X. Liu, X. M. Zhu, Q. Miao, H. Y. Ye, Z. Y. Zhang, and Y. M. Li, “Hyperglycemia induced by glucocorticoids in nondiabetic patients: a meta-analysis,” Annals of Nutrition and Metabolism, vol. 65, no. 4, pp. 324–332, 2014. View at Publisher · View at Google Scholar
  32. American Diabetes Association, “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 36, supplement 1, pp. S67–S74, 2013. View at Publisher · View at Google Scholar
  33. C. Giordano, V. Guarnotta, R. Pivonello et al., “Is diabetes in Cushing's syndrome only a consequence of hypercortisolism?” European Journal of Endocrinology, vol. 170, no. 2, pp. 311–319, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. A. G. Rockall, S. A. Sohaib, D. Evans et al., “Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography,” European Journal of Endocrinology, vol. 149, no. 6, pp. 543–548, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Smets, E. Meyer, B. Maddens, and S. Daminet, “Cushing's syndrome, glucocorticoids and the kidney,” General and Comparative Endocrinology, vol. 169, no. 1, pp. 1–10, 2010. View at Publisher · View at Google Scholar · View at Scopus