Determinants of Secondary Hyperparathyroidism in Bariatric Patients after Roux-en-Y Gastric Bypass or Sleeve Gastrectomy: A Pilot Study
Table 2
Comparison of main anthropometric and biochemical parameters according to the presence of secondary hyperparathyroidism after surgery, independently for men/premenopausal women and for postmenopausal women.
Mean ± SD or frequency (%)
ANOVA or
SHPT
Controls
P value
Men and premenopausal women ()
Age (years)
0.335
BMI (kg/m2)
0.484
WHR
0.544
Excess weight loss (%)
0.654
Duration after surgery (years)
0.292
Parathormone (pg/dL)
<0.001
25(OH)VitD (ng/dL)
0.028
Log-creatinine (mg/dL)
0.508
Calcium (mg/dL)
0.042
Magnesium (mg/dL)
0.036
Phosphorus (mg/dL)
0.592
Folate deficiency (<4 ng/mL, %)
23.1%
40%
0.339
Supplemental calcium and/or vitamin D (%)
4.17%
4.76%
0.923
Suboptimal vitamin D
100%
85.7%
0.055
Vitamin D deficiency
58.3%
33.3%
0.094
Current smoking
37.5%
66.7%
0.051
Type of surgery: sleeve gastrectomy1
22.7%
28.6%
0.661
Postmenopausal women ()
Secondary hyperparathyroidism
Age (years)
0.166
Menopausal age (years)
0.068#
BMI (kg/m2)
0.519
WHR
0.152
Excess weight loss (%)
0.163
Log-duration after surgery (years)
0.343
Parathormone (pg/dL)
<0.001
25(OH)VitD (ng/dL)
0.219
Creatinine (mg/dL)
0.734
Calcium (mg/dL)
0.641
Magnesium (mg/dL)
0.977
Phosphorus (mg/dL)
0.912
Folate deficiency (<4 ng/mL, %)
16.7%
36.3%
0.394
Supplemental calcium and/or vitamin D (%)
21.4%
7.4%
0.193
Suboptimal vitamin D
92.9%
92.6%
0.975
Vitamin D deficiency
78.6%
40.7%
0.021
Current smoking
28.6%
55.6%
0.100
Type of surgery: sleeve gastrectomy1
61.5%
40.7%
0.217
SHPT: secondary hyperparathyroidism; BMI: body mass index; WHR: waist to hip ratio; 25(OH)VitD: 25-hydroxyvitamin D. 1Reference category: Roux-en-Y gastric bypass; statistical significance was set at the level of P value <0.05. #Mann-Whitney test was used due to insufficient normality of data.
