Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2016, Article ID 1794894, 7 pages
http://dx.doi.org/10.1155/2016/1794894
Research Article

Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

1Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
2Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China
3Sanming City Hospital of Integrated Traditional Chinese and Western Medicine, Sanming 365000, China
4Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China

Received 16 January 2016; Revised 13 April 2016; Accepted 22 May 2016

Academic Editor: Xiangbing Wang

Copyright © 2016 Jie Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Yang, J. Lu, J. Weng et al., “Prevalence of diabetes among men and women in China,” The New England Journal of Medicine, vol. 362, no. 12, pp. 1090–1101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. M. F. Holick, “The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action,” Molecular Aspects of Medicine, vol. 29, no. 6, pp. 361–368, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. F. Holick, “Vitamin D: extraskeletal health,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 381–400, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes, “The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 6, pp. 2017–2029, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Mitri, B. Dawson-Hughes, F. B. Hu, and A. G. Pittas, “Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial,” American Journal of Clinical Nutrition, vol. 94, no. 2, pp. 486–494, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Talaei, M. Mohamadi, and Z. Adgi, “The effect of vitamin D on insulin resistance in patients with type 2 diabetes,” Diabetology & Metabolic Syndrome, vol. 5, article 8, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. A. G. Pittas, Q. Sun, J. E. Manson, B. Dawson-Hughes, and F. B. Hu, “Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women,” Diabetes Care, vol. 33, no. 9, pp. 2021–2023, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. G. Pittas, J. Nelson, J. Mitri et al., “Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the diabetes prevention program,” Diabetes Care, vol. 35, no. 3, pp. 565–573, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Mitri, M. D. Muraru, and A. G. Pittas, “Vitamin D and type 2 diabetes: a systematic review,” European Journal of Clinical Nutrition, vol. 65, no. 9, pp. 1005–1015, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. C. E. A. Chagas, M. C. Borges, L. A. Martini, and M. M. Rogero, “Focus on vitamin D, inflammation and type 2 diabetes,” Nutrients, vol. 4, no. 1, pp. 52–67, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Lim, M. J. Kim, S. H. Choi et al., “Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects,” The American Journal of Clinical Nutrition, vol. 97, no. 3, pp. 524–530, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Scragg, I. Holdaway, V. Singh, P. Metcalf, J. Baker, and E. Dryson, “Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 27, no. 3, pp. 181–188, 1995. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Deleskog, A. Hilding, K. Brismar, A. Hamsten, S. Efendic, and C.-G. Östenson, “Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance,” Diabetologia, vol. 55, no. 6, pp. 1668–1678, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. K. C. Chiu, A. Chu, V. L. W. Go, and M. F. Saad, “Hypovitaminosis D is associated with insulin resistance and β cell dysfunction,” The American Journal of Clinical Nutrition, vol. 79, no. 5, pp. 820–825, 2004. View at Google Scholar · View at Scopus
  15. B. García-Bailo, K. Roke, D. M. Mutch, A. El-Sohemy, and A. Badawi, “Association between circulating ascorbic acid, -tocopherol, 25-hydroxyvitamin D, and plasma cytokine concentrations in young adults: a cross-sectional study,” Nutrition & Metabolism, vol. 9, article 102, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Garcia-Bailo, A. El-Sohemy, P. S. Haddad et al., “Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress,” Biologics: Targets and Therapy, vol. 5, pp. 7–19, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Badawi, A. Klip, P. Haddad et al., “Type 2 diabetes mellitus and inflammation: prospects for biomarkers of risk and nutritional intervention,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 3, pp. 173–186, 2010. View at Google Scholar
  18. H. L. Gulseth, I. M. F. Gjelstad, A. C. Tierney et al., “Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome,” Diabetes Care, vol. 33, no. 4, pp. 923–925, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Yousefzadeh, S. A. Shapses, and X. Wang, “Vitamin D binding protein impact on 25-hydroxyvitamin D levels under different physiologic and pathologic conditions,” International Journal of Endocrinology, vol. 2014, Article ID 981581, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline,” The Journal of Clinical Endocrinology and Metabolism, vol. 96, pp. 1911–1930, 2011. View at Google Scholar
  21. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey,” Diabetes Care, vol. 27, no. 12, pp. 2813–2818, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Chonchol and R. Scragg, “25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey,” Kidney International, vol. 71, no. 2, pp. 134–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Bonora, G. Formentini, F. Calcaterra et al., “HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study,” Diabetes Care, vol. 25, no. 7, pp. 1135–1141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Christakos, D. V. Ajibade, P. Dhawan, A. J. Fechner, and L. J. Mady, “Vitamin D: metabolism,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 243–253, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. J. C. Gallagher, M. Peacock, V. Yalamanchili, and L. M. Smith, “Effects of vitamin D supplementation in older African American women,” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 3, pp. 1137–1146, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Andersen, C. Brot, J. Jakobsen et al., “Seasonal changes in vitamin D status among Danish adolescent girls and elderly women: the influence of sun exposure and vitamin D intake,” European Journal of Clinical Nutrition, vol. 67, no. 3, pp. 270–274, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. D. M. Freedman, E. K. Cahoon, P. Rajaraman et al., “Sunlight and other determinants of circulating 25-hydroxyvitamin D levels in black and white participants in a nationwide US study,” American Journal of Epidemiology, vol. 177, no. 2, pp. 180–192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. I. Kostoglou-Athanassiou, P. Athanassiou, A. Gkountouvas, and P. Kaldrymides, “Vitamin D and glycemic control in diabetes mellitus type 2,” Therapeutic Advances in Endocrinology and Metabolism, vol. 4, no. 4, pp. 122–128, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Bachali, K. Dasu, K. Ramalingam, and J. N. Naidu, “Vitamin D deficiency and insulin resistance in normal and type 2 diabetes subjects,” Indian Journal of Clinical Biochemistry, vol. 28, no. 1, pp. 74–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Gagnon, Z. X. Lu, D. J. Magliano et al., “Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian diabetes, obesity and lifestyle study),” Diabetes Care, vol. 34, no. 5, pp. 1133–1138, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. P.-M. Bourlon, B. Billaudel, and A. Faure-Dussert, “Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas,” The Journal of Endocrinology, vol. 160, no. 1, pp. 87–95, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Maestro, J. Campión, N. Dávila, and C. Calle, “Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells,” Endocrine Journal, vol. 47, no. 4, pp. 383–391, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. L.-H. Li, X.-Y. Yin, C.-Y. Yao, X.-C. Zhu, and X.-H. Wu, “Serum 25-hydroxyvitamin D, parathyroid hormone, and their association with metabolic syndrome in Chinese,” Endocrine, vol. 44, no. 2, pp. 465–472, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. O. Wang, M. Nie, Y. Y. Hu et al., “Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women,” Biomedical and Environmental Sciences, vol. 25, no. 4, pp. 399–406, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Lu, Z. Yu, A. Pan et al., “Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals,” Diabetes Care, vol. 32, no. 7, pp. 1278–1283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. X. Cai, Z. Hu, L. Chen, X. Han, and L. Ji, “Analysis of the associations between vitamin D and albuminuria or β-cell function in Chinese type 2 diabetes,” BioMed Research International, vol. 2014, Article ID 640909, 5 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. R. P. Heaney, C. B. French, S. Nguyen et al., “A novel approach localizes the association of vitamin D status with insulin resistance to one region of the 25-Hydroxyvitamin D continuum,” Advances in Nutrition, vol. 4, no. 3, pp. 303–310, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Badawi, S. Sayegh, E. Sadoun, M. Al-Thani, P. Arora, and P. S. Haddad, “Relationship between insulin resistance and plasma vitamin D in adults,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 7, pp. 297–303, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. P. R. Von Hurst, W. Stonehouse, and J. Coad, “Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial,” British Journal of Nutrition, vol. 103, no. 4, pp. 549–555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. E. S. Ford, U. A. Ajani, L. C. McGuire, and S. Liu, “Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults,” Diabetes Care, vol. 28, no. 5, pp. 1228–1230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. D. R. Brenner, P. Arora, B. Garcia-Bailo et al., “Plasma vitamin D levels and risk of metabolic syndrome in Canadians,” Clinical and Investigative Medicine, vol. 34, no. 6, pp. E377–E384, 2011. View at Google Scholar · View at Scopus
  43. S. Kayaniyil, R. Vieth, R. Retnakaran et al., “Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes,” Diabetes Care, vol. 33, no. 6, pp. 1379–1381, 2010. View at Publisher · View at Google Scholar
  44. L. J. Baier, A. M. Dobberfuhl, R. E. Pratley, R. L. Hanson, and C. Bogardus, “Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians,” The Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 8, pp. 2993–2996, 1998. View at Publisher · View at Google Scholar · View at Scopus
  45. M. F. McDermott, A. Ramachandran, B. W. Ogunkolade et al., “Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians,” Diabetologia, vol. 40, no. 8, pp. 971–975, 1997. View at Publisher · View at Google Scholar · View at Scopus
  46. M. A. Pani, M. Knapp, H. Donner et al., “Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans,” Diabetes, vol. 49, no. 3, pp. 504–507, 2000. View at Publisher · View at Google Scholar · View at Scopus
  47. M. T. Malecki, T. Klupa, P. Wolkow, J. Bochenski, K. Wanic, and J. Sieradzki, “Association study of the vitamin D: 1Alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population,” Diabetes and Metabolism, vol. 29, no. 2, pp. 119–124, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. B. García-Bailo, J. Jamnik, L. A. Da Costa, A. Badawi, and A. El-Sohemy, “Genetic variation in the Vitamin D receptor, plasma 25-hydroxyvitamin D, and biomarkers of cardiometabolic disease in caucasian young adults,” Journal of Nutrigenetics and Nutrigenomics, vol. 6, no. 4-5, pp. 256–267, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. C. Cade and A. W. Norman, “Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo,” Endocrinology, vol. 119, no. 1, pp. 84–90, 1986. View at Publisher · View at Google Scholar · View at Scopus
  50. C. Beaulieu, R. Kestekian, J. Havrankova, and M. Gascon-Barre, “Calcium is essential in normalizing intolerance to glucose that accompanies vitamin D depletion in vivo,” Diabetes, vol. 42, no. 1, pp. 35–43, 1993. View at Publisher · View at Google Scholar · View at Scopus
  51. D. Teegarden and S. S. Donkin, “Vitamin D: emerging new roles in insulin sensitivity,” Nutrition Research Reviews, vol. 22, no. 1, pp. 82–92, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. H. A. Bischoff, M. Borchers, F. Gudat et al., “In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue,” The Histochemical Journal, vol. 33, no. 1, pp. 19–24, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Ashraf and J. A. Alvarez, “Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis,” International Journal of Endocrinology, vol. 2010, Article ID 351385, 18 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. A. W. Norman, “Minireview: vitamin D receptor: new assignments for an already busy receptor,” Endocrinology, vol. 147, no. 12, pp. 5542–5548, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Li, M. E. Byrne, E. Chang et al., “1α,25-Dihydroxyvitamin D hydroxylase in adipocytes,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 112, no. 1–3, pp. 122–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. B.-W. Ogunkolade, B. J. Boucher, J. M. Prahl et al., “Vitamin D Receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians,” Diabetes, vol. 51, no. 7, pp. 2294–2300, 2002. View at Publisher · View at Google Scholar · View at Scopus
  57. N. G. Forouhi, J. Luan, A. Cooper, B. J. Boucher, and N. J. Wareham, “Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the medical research council ely prospective study 1990-2000,” Diabetes, vol. 57, no. 10, pp. 2619–2625, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. N. R. Pinelli, L. A. Jaber, M. B. Brown, and W. H. Herman, “Serum 25-hydroxy vitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans,” Diabetes Care, vol. 33, no. 6, pp. 1373–1375, 2010. View at Publisher · View at Google Scholar · View at Scopus