Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2016 (2016), Article ID 1956740, 9 pages
http://dx.doi.org/10.1155/2016/1956740
Research Article

Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas

1Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, Brazil
2Pediatric Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
3Thyroid Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, Brazil
4Molecular Medicine Laboratory, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, Brazil
5Division of Endocrinology, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, Brazil

Received 10 September 2015; Accepted 28 January 2016

Academic Editor: Maria L. Dufau

Copyright © 2016 Maria Isabel Cunha Vieira Cordioli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (≥10–18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified.