Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

Figure 1

Circadian Clock. Positive regulation of clock genes Bmal1 and Clock stimulates promoter of negative regulators Per1–3, Cry 1-2, and controlled clock genes StAR, 3β-HSD, DBP, VEGF, Hexokinase, and Wee-1. Moreover, the molecular clock regulates the deacetylase activity of SIRT1 by regulation of NAD⁺/NADH ratio.