Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

Table 1

Polymorphisms of clock genes associated with metabolic disorders.

Gene	SNPs	Variation	Localization	Pathology	Reference
Clock	rs1801260	T>C	Chromosome 4; 3′ UTR; Homo sapiens	Dyslipidemia and diabetes	[59, 60]
	rs10002541	T>C	Chromosome 4; intron; Homo sapiens	Diabetes	[62]
	rs12649507	G>A	Chromosome 4; intron; Homo sapiens	Food intake	[64]
	rs4580704	G>C	Chromosome 4; intron; Homo sapiens	Diabetes, cardiovascular disease, and HDL level	[61, 63]
	rs3749474	C>T	Chromosome 4; 3-UTR; Homo sapiens	Food intake	[65]
	rs4864546	G>A	Chromosome 4; near gene-5′; Homo sapiens.	Diabetes	[62]
Per2	rs7602358	G>T	Chromosome 2; intron; Homo sapiens	Diabetes	[32]
Per3	rs57875989	Deletion/insertion	Chromosome 1; 5′ near gene; Homo sapiens	Diabetes	[57, 58]
Bmal1	rs11022775	C>T	Chromosome 11; intron; Homo sapiens	Gestational diabetes mellitus	[33]
	rs7950226	G>A	Chromosome 11; intron; Homo sapiens	Gestational diabetes mellitus	[33]
Bmal2	rs7958822	G>A	Chromosome 12; intron; Homo sapiens	Diabetes	[56]
Cry1	rs12315175	T>C	Chromosome 12; Homo sapiens	Diabetes	[53]
	rs8192440	A>G	Chromosome 12; CDS; Homo sapiens	Diabetes	[54]
Cry2	rs11605924	A>C	Chromosome 11; intron; Homo sapiens	Diabetes	[54]
	rs2292912	C>G/T	Chromosome 11; intron; Homo sapiens	Diabetes	[53]