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International Journal of Endocrinology
Volume 2016, Article ID 2967578, 11 pages
http://dx.doi.org/10.1155/2016/2967578
Review Article

Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India

1Providence Endocrine and Diabetes Specialty Centre, Thiruvananthapuram, Kerala, India
2Lead Endocrinology, Global Medical, Safety and CMO, Merck, Darmstadt, Germany
3Centre for Diabetes and Endocrine Care, Bangalore, Karnataka, India
4Biopharma, NDD and Endocrinology, Merck Specialties Pvt. Ltd., Mumbai, India

Received 13 April 2016; Accepted 15 September 2016

Academic Editor: Darío A. Castroviejo

Copyright © 2016 Mathew John et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. U. Nwosu and M. M. Lee, “Evaluation of short and tall stature in children,” American Family Physician, vol. 78, no. 5, pp. 597–604, 2008. View at Google Scholar · View at Scopus
  2. J. Lantos, M. Siegler, and L. Cuttler, “Ethical issues in growth hormone therapy,” Journal of the American Medical Association, vol. 261, no. 7, pp. 1020–1024, 1989. View at Publisher · View at Google Scholar · View at Scopus
  3. S.-G. Shu, Y.-D. Chen, and C.-S. Chi, “Clinical evaluation of short children referred by school screening: an analysis of 655 children,” Acta Paediatrica Taiwanica, vol. 43, no. 6, pp. 340–344, 2002. View at Google Scholar · View at Scopus
  4. R. Lindsay, M. Feldkamp, D. Harris, J. Robertson, and M. Rallison, “Utah growth study: growth standards and the prevalence of growth hormone deficiency,” Journal of Pediatrics, vol. 125, no. 1, pp. 29–35, 1994. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Kaur and S. R. Phadke, “Analysis of short stature cases referred for genetic evaluation,” Indian Journal of Pediatrics, vol. 79, no. 12, pp. 1597–1600, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. Zayed, M. K. Mustafa Ali, M. A. Al-Ani, M. S. Momani, and A.-M. F. Yousef, “The prevalence of isolated growth hormone deficiency among children of short stature in Jordan and its relationship with consanguinity,” Clinical Endocrinology, vol. 81, no. 6, pp. 876–882, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Corneli, R. Baldelli, C. Di Somma et al., “Occurence of GH deficiency in adult patients who underwent neurosurgery in the hypothalamus-pituitary area for non-functioning tumour masses,” Growth Hormone and IGF Research, vol. 13, no. 2-3, pp. 104–108, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Baldelli, A. Bianchi, F. Diacono et al., “Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas,” Journal of Endocrinological Investigation, vol. 28, no. 2, pp. 157–161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Colaco, M. Desai, and C. S. Choksi, “Short stature in Indian children: the extent of the problem,” The Indian Journal of Pediatrics, vol. 58, supplement 5, pp. 57–58, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. A. H. Zargar, B. A. Laway, S. R. Masoodi, A. I. Wani, and M. Salahuddin, “An aetiological profile of short stature in the Indian subcontinent,” Journal of Paediatrics and Child Health, vol. 34, no. 6, pp. 571–576, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Tanner, H. Goldstein, and R. H. Whitehouse, “Standards for children's height at ages 2–9 years allowing for height of parents,” Archives of Disease in Childhood, vol. 45, no. 244, pp. 755–762, 1970. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Boersma, H. J. A. Wynne, and J. M. Wit, “A mathematical model describing catch-up growth in celiac disease,” Acta Paediatrica, vol. 83, no. 10, pp. 1097–1099, 1994. View at Publisher · View at Google Scholar · View at Scopus
  13. S. van Buuren, D. J. A. Bonnemaijer-Kerckhoffs, F. K. Grote, J. M. Wit, and P. H. Verkerk, “Many referrals under Dutch short stature guidelines,” Archives of Disease in Childhood, vol. 89, no. 4, pp. 351–352, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Saari, “Modern methods for auxological screening of growth disorders in children,” http://epublications.uef.fi/pub/urn_isbn_978-952-61-1723-2/urn_isbn_978-952-61-1723-2.pdf
  15. P. Bang, S. Faisal Ahmed, J. Argente et al., “Identification and management of poor response to growth-promoting therapy in children with short stature,” Clinical Endocrinology, vol. 77, no. 2, pp. 169–181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. K. S. Alatzoglou, E. A. Webb, P. Le Tissier, and M. T. Dattani, “Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances,” Endocrine Reviews, vol. 35, no. 3, pp. 376–432, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. K. C. J. Yuen, L. E. Chong, and S. A. Rhoads, “Evaluation of adult growth hormone deficiency: current and future perspectives,” in Endotext [Internet], L. J. De Groot, G. Chrousos, K. Dungan et al., Eds., MDText.com, Inc., South Dartmouth, Mass, USA, 2000. View at Google Scholar
  18. S. M. Shalet, A. Toogood, A. Rahim, and B. M. D. Brennan, “The diagnosis of growth hormone deficiency in children and adults,” Endocrine Reviews, vol. 19, no. 2, pp. 203–223, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. D. S. Hardin, “Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin),” Biologics: Targets and Therapy, vol. 2, no. 4, pp. 655–661, 2008. View at Google Scholar · View at Scopus
  20. S. Loche, L. Carta, A. Ibba, and C. Guzzetti, “Growth hormone treatment in non-growth hormone-deficient children,” Annals of Pediatric Endocrinology & Metabolism, vol. 19, no. 1, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  21. P. Cohen, A. D. Rogol, C. L. Deal et al., “Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop,” The Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4210–4217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. P. S. N. Menon, R. K. Menon, and A. Gupta, “Normal variant short stature,” The Indian Journal of Pediatrics, vol. 50, no. 5, pp. 533–535, 1983. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Raghupathy, “Growth hormone deficiency: a vellore experience: 1986–1990,” The Indian Journal of Pediatrics, vol. 58, no. supplement 5, p. 79, 1991. View at Publisher · View at Google Scholar · View at Scopus
  24. S. K. Kota, S. Jammula, K. Gayatri, and S. K. Kota, “Evaluation of insulin-like growth factor-1 and its impact on growth hormone therapy in growth hormone-deficient Indian children,” International Journal of Endocrinology and Metabolism, vol. 9, no. 1, pp. 258–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. V. H. Ekbote, V. T. Rustagi, V. V. Khadilkar, A. V. Khadilkar, and S. A. Chiplonkar, “Evaluation of insulin-like growth factor-1 in Indian growth hormone-deficient children on growth hormone therapy,” Endocrine Research, vol. 36, no. 3, pp. 109–115, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. V. V. Khadilkar, A. V. Khadilkar, M. Nandy, and G. B. Maskati, “Multicentric study of efficacy and safety of growth hormone use in growth hormone deficient children in India,” Indian Journal of Pediatrics, vol. 74, no. 1, pp. 51–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. P. S. N. Menon, A. Virmani, and A. K. Sethi, “Biosynthetic growth hormone therapy in children with growth hormone deficiency: experience at AIIMS, New Delhi,” The Indian Journal of Pediatrics, vol. 58, supplement 5, pp. 71–77, 1991. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Bajpai, M. Kabra, A. K. Gupta, and P. S. N. Menon, “Growth pattern and skeletal maturation following growth hormone therapy in growth hormone deficiency: factors influencing outcome,” Indian Pediatrics, vol. 43, no. 7, pp. 593–599, 2006. View at Google Scholar · View at Scopus
  29. M. K. Garg, R. Pakhetra, M. K. Dutta, and A. Gundgurthi, “Response to growth hormone therapy in Indian patients,” Indian Journal of Pediatrics, vol. 77, no. 6, pp. 639–642, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. V. Kannan and K. Usharani, “Human growth hormone therapy: longterm responses in 30 children with growth hormone deficiency,” The Indian Journal of Pediatrics, vol. 58, supplement 5, pp. 65–69, 1991. View at Publisher · View at Google Scholar · View at Scopus
  31. V. Khadilkar, S. Yadav, K. K. Agrawal et al., “Revised IAP growth charts for height, weight and body mass index for 5- to 18-year-old Indian children,” Indian Pediatrics, vol. 52, no. 1, pp. 47–55, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. V. Khadilkar and A. Khadilkar, “Growth charts: a diagnostic tool,” Indian Journal of Endocrinology and Metabolism, vol. 15, no. 7, pp. 166–171, 2011. View at Publisher · View at Google Scholar
  33. V. V. Khadilkar and A. V. Khadilkar, “Revised Indian Academy of Pediatrics 2015 growth charts for height, weight and body mass index for 5–18-year-old Indian children,” Indian Journal of Endocrinology and Metabolism, vol. 19, no. 4, pp. 470–476, 2015. View at Publisher · View at Google Scholar
  34. V. V. Khadilkar, A. V. Khadilkar, P. Choudhury, K. N. Agarwal, D. Ugra, and N. K. Shah, “IAP growth monitoring guidelines for children from birth to 18 years,” Indian Pediatrics, vol. 44, no. 3, pp. 187–197, 2007. View at Google Scholar · View at Scopus
  35. V. Khadilkar and S. Phanse, “Growth charts from controversy to consensus,” Indian Journal of Endocrinology and Metabolism, vol. 16, supplement 2, pp. S185–S187, 2012. View at Google Scholar
  36. A. Virmani, P. S. Menon, M. G. Karmarkar, P. G. Gopinath, and A. K. Padhy, “Profile of thyroid disorders in a referral centre in north India,” Indian Pediatrics, vol. 26, no. 3, pp. 265–269, 1989. View at Google Scholar · View at Scopus
  37. S. M. de Muinck Keizer-Schrama, “Consensus ‘diagnosis of short stature in children.’National Organization for Quality Assurance in Hospitals,” Nederlands Tijdschrift Voor Geneeskunde, vol. 142, no. 46, pp. 2519–2525, 1998. View at Google Scholar
  38. F. K. Grote, W. Oostdijk, S. M. P. F. De Muinck Keizer-Schrama et al., “Referral patterns of children with poor growth in primary health care,” BMC Public Health, vol. 7, article 77, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. World Health Organization, “Training course on child growth assessment. WHO child growth standards,” http://www.who.int/childgrowth/training/module_c_interpreting_indicators.pdf
  40. M. Haymond, A.-M. Kappelgaard, P. Czernichow, B. M. Biller, K. Takano, and W. Kiess, “Early recognition of growth abnormalities permitting early intervention,” Acta Paediatrica, vol. 102, no. 8, pp. 787–796, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Bhutia, “Protein energy malnutrition in India: the plight of our under five children,” Journal of Family Medicine and Primary Care, vol. 3, no. 1, pp. 63–67, 2014. View at Publisher · View at Google Scholar
  42. P. Nath, J. Kumar, S. Rahman, and M. Rai, “Short Stature: Evaluation and Management. Medicine Update 2013,” http://www.apiindia.org/medicine_update_2013/chap137.pdf
  43. R. Ayling, “More guidance on growth hormone deficiency,” Journal of Clinical Pathology, vol. 57, no. 2, pp. 123–125, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. L. K. Nieman, B. M. K. Biller, J. W. Findling et al., “The diagnosis of Cushing's syndrome: an endocrine society clinical practice guideline,” The Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 5, pp. 1526–1540, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. T. Stanley, “Diagnosis of growth hormone deficiency in childhood,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 19, no. 1, pp. 47–52, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Loche, C. Bizzarri, M. Maghnie et al., “Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency,” The Journal of Pediatrics, vol. 140, no. 4, pp. 445–449, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. H. S. Lee and J. S. Hwang, “Influence of body mass index on growth hormone responses to classic provocative tests in children with short stature,” Neuroendocrinology, vol. 93, no. 4, pp. 259–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Juul and N. E. Skakkebaek, “Prediction of the outcome of growth hormone provocative testing in short children by measurement of serum levels of insulin-like growth factor I and insulin-like growth factor binding protein 3,” The Journal of Pediatrics, vol. 130, no. 2, pp. 197–204, 1997. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Cianfarani, T. Tondinelli, G. L. Spadoni, G. Scirè, S. Boemi, and B. Boscherini, “Height velocity and IGF-I assessment in the diagnosis of childhood onset GH insufficiency: do we still need a second GH stimulation test?” Clinical Endocrinology, vol. 57, no. 2, pp. 161–167, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. D. T. Wyatt, D. Mark, and A. Slyper, “Survey of growth hormone treatment practices by 251 pediatric endocrinologists,” The Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 11, pp. 3292–3297, 1995. View at Google Scholar · View at Scopus
  51. C. Deal and J. C. Décarie, Magenetic Resonance Imaging in Congenital Hypopituitarism: Technical Aspects, Remedica Medical Education and Publishing, London, UK, 2007.
  52. R. Pfäffle and W. F. Blum, Understanding the Genetic of Growth Hormone Deficiency. A Reference Guide, TMG Healthcare Communications, 2000.
  53. M. P. Desai, P. S. Upadhye, T. Kamijo et al., “Growth hormone releasing hormone receptor (GHRH-R) gene mutation in Indian children with familial isolated growth hormone deficiency: a study from western India,” Journal of Pediatric Endocrinology & Metabolism, vol. 18, no. 10, pp. 955–973, 2005. View at Google Scholar · View at Scopus
  54. R. C. Olney, H. Bükülmez, C. F. Bartels et al., “Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature,” The Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 4, pp. 1229–1232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. O. Nilsson, M. H. Guo, N. Dunbar et al., “Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations,” Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 8, pp. E1510–E1518, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. M. T. Muñoz-Calvo, V. Barrios, J. Pozo et al., “OR03-1 a new syndrome of short stature, mild microcephaly, skeletal abnormalities and high circulating IGF1, IGFBP3 and ALS associated with a homozygous mutation in the gene for pregnancy-associated plasma protein A2 (PAPP-A2, pappalysin2),” in Proceedings of the Endocrine Society's 97th Annual Meeting and Expo, San Diego, Calif, USA, 2015.
  57. F. Haverkamp, L. Johansson, H. Dumas et al., “Observations of nonadherence to recombinant human growth hormone therapy in clinical practice,” Clinical Therapeutics, vol. 30, no. 2, pp. 307–316, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Prakasam, “Growth hormone therapy effective in treatment of variety of hormone deficiency disorders in children,” Managed Care Interface, supplement, pp. 3–5, 2005. View at Google Scholar
  59. Z. A. Efstathiadou, A. Bargiota, A. Chrisoulidou et al., “Impact of gsp mutations in somatotroph pituitary adenomas on growth hormone response to somatostatin analogs: a meta-analysis,” Pituitary, vol. 18, no. 6, pp. 861–867, 2015. View at Publisher · View at Google Scholar · View at Scopus
  60. M. H. Shanik, P. D. Cao, and W. H. Ludlam, “Historical response rates of somatostatin analogues in the treatment of acromegaly: a systematic review,” Endocrine Practice, vol. 22, no. 3, pp. 350–356, 2016. View at Publisher · View at Google Scholar
  61. J. M. Wit, M. B. Ranke, K. Albertsson-Wikland et al., “Personalized approach to growth hormone treatment: clinical use of growth prediction models,” Hormone Research in Paediatrics, vol. 79, no. 5, pp. 257–270, 2013. View at Publisher · View at Google Scholar
  62. M. Ranke, A. Lindberg, C. T. Cowell et al., “Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database),” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 1, pp. 125–131, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. B. K. Aydin, Z. Aycan, Z. Şiklar et al., “Adherence to growth hormone therapy: results of a multicenter study,” Endocrine Practice, vol. 20, no. 1, pp. 46–51, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. S. L. Smith, P. C. Hindmarsh, and C. G. D. Brook, “Compliance with growth hormone treatment—are they getting it?” Archives of Disease in Childhood, vol. 68, no. 1, pp. 91–93, 1993. View at Publisher · View at Google Scholar · View at Scopus
  65. B. G. Fisher and C. L. Acerini, “Understanding the growth hormone therapy adherence paradigm: a systematic review,” Hormone Research in Paediatrics, vol. 79, no. 4, pp. 189–196, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Bozzola, S. Pagani, L. Iughetti, C. Maffeis, E. Bozzola, and C. Meazza, “Adherence to growth hormone therapy: a practical approach,” Hormone Research in Paediatrics, vol. 81, no. 5, pp. 331–335, 2014. View at Publisher · View at Google Scholar · View at Scopus
  67. J. Muller, N. E. Skakkebaek, B. B. Jacobsen et al., “Norditropin SimpleXx: a liquid human growth hormone formulation, a pen system and an auto-insertion device,” Hormone Research, vol. 51, supplement 3, pp. 109–112, 1999. View at Google Scholar
  68. K. Iyoda, T. Moriwake, Y. Seino, and H. Niimi, “The clinical usefulness of liquid human growth hormone (hGH) (Norditropin SimpleXx(TM)) in the treatment of GH deficiency,” Hormone Research, vol. 51, no. 3, pp. 113–115, 1999. View at Google Scholar · View at Scopus
  69. A.-M. Kappelgaard, A. Bojesen, K. Skydsgaard, I. Sjögren, and T. Laursen, “Liquid growth hormone: preservatives and buffers,” Hormone Research, vol. 62, supplement 3, pp. 98–103, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Bozzola, M. Colle, M. Halldin-Stenlid, S. Larroque, and M. Zignani, “Treatment adherence with the easypod growth hormone electronic auto-injector and patient acceptance: Survey results from 824 children and their parents,” BMC Endocrine Disorders, vol. 11, article 4, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. B. B. Bercu, F. T. Murray, S. D. Frasier et al., “Long-term therapy with recombinant human growth hormone (Saizen®) in children with idiopathic and organic growth hormone deficiency,” Endocrine, vol. 15, no. 1, pp. 43–49, 2001. View at Publisher · View at Google Scholar · View at Scopus
  72. D. K. Agarwal, K. N. Agarwal, S. K. Upadhyay, R. Mittal, R. Prakash, and S. Rai, “Physical and sexual growth pattern of affluent Indian children from 5 to 18 years of age,” Indian Pediatrics, vol. 29, no. 10, pp. 1203–1282, 1992. View at Google Scholar · View at Scopus
  73. P. G. Murray, M. T. Dattani, and P. E. Clayton, “Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence,” Archives of Disease in Childhood, vol. 101, no. 1, pp. 96–100, 2016. View at Publisher · View at Google Scholar · View at Scopus
  74. D. R. Clemmons, “Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays,” Clinical Chemistry, vol. 57, no. 4, pp. 555–559, 2011. View at Publisher · View at Google Scholar · View at Scopus