Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome

Table 1

Baseline characteristics of Klinefelter syndrome (KS) patients and controls.

	KS	Controls	p
Subjects, number	40	80	—
Age, yrs	11.96 3.57		—
Children			—
Adolescents			—
Height, SDS			—
Children			—
Adolescents			—
BMI, SDS			—
Children			—
Adolescents			—
WC, SDS			—
AD-SoS, z-score			<0.005
Children			NS
Adolescents			<0.005
BTT, z-score			<0.0005
Children			<0.005
Adolescents			<0.05
Calcium intake, mg/day			NS
Vitamin D intake			NS
Total calcium, mmol/L			NS
Ionised calcium, mmol/L			NS
Phosphorus, mmol/L			NS
PTH, pg/mL			<0.0001
Children			<0.005
Adolescents			<0.0001
BSAP, U/L			<0.005
Osteocalcin, ng/mL			<0.05
Urinary deoxypyridinoline, nM/mM creatinine			NS
25(OH)D, ng/mL			<0.0001
1,25(OH)2D, pg/mL			<0.0001
Total testosterone, nmol/L			—
LH, U/L			—
FSH, U/L			<0.05
Inhibin B, pg/mL			<0.0001
Estradiol, pmol/L			<0.05
Testicular volume, cc			<0.0001

BMI: body mass index; WC: waist circumference; 25(OH)D: 25-hydroxyvitamin D; 1,25(OH)2D: 1,25-dihydroxyvitamin D; PTH: parathyroid hormone.