The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 4

Summary of other clinical parameters.

Study and publication year	Other outcomes
Libman et al., 2015 [15]	No significant differences were observed between groups in percentile changes in blood pressure or the levels of lipids, inflammatory markers, C-reactive protein, or C peptide.
Nwosu et al., 2015 [13]	There were no significant differences between the groups in changes in blood pressure, the level of insulin sensitivity factor (ISF), ideal blood glucose (IBG), or insulin-to-carbohydrate ratio (ICR).
Nadeau et al., 2015 [14]	No significant differences were observed in changes in blood pressure or lipid levels between groups.
Särnblad et al., 2003 [6]	Peripheral insulin sensitivity was increased in the group that received metformin. No differences were observed in the levels of blood lipids, insulin-like growth factor I (IGF-I), or IGF-binding protein-1 (IGFBP-1) between the two groups.
Hamilton et al., 2003 [17]	No changes in insulin sensitivity were observed according to the frequently sampled intravenous glucose tolerance test (FSIGT). Cholesterol and triglyceride levels did not change during the study period.