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International Journal of Endocrinology
Volume 2016, Article ID 4581094, 6 pages
Research Article

Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism

1Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
2Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain
3Radiology Department, Reina Sofia University Hospital, Córdoba, Spain

Received 21 February 2016; Revised 25 June 2016; Accepted 4 August 2016

Academic Editor: Thomas J. Fahey

Copyright © 2016 Paloma Moreno-Moreno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods. A retrospective descriptive study was performed including patients with endogenous hyperinsulinism who underwent ASVS. The histopathological diagnosis in patients who underwent a surgical procedure was used as the reference for the statistical study of the accuracy of this technique. Results. 30 patients were included with endogenous hyperinsulinism and nonconclusive imaging diagnosis was included. ASVS was performed in all cases. Surgery was performed in 20 cases. Insulinoma was removed in 19 patients; the location of all cases was detected in the ASVS. All cases of endogenous hyperinsulinism had a positive result for the ASVS, with this association being statistically significant (; ). A good and statistically significant agreement was obtained between histopathologic diagnosis and ASVS results (, ). Conclusions. ASVS is a useful procedure in the localization diagnosis of endogenous hyperinsulinism undetected by other imaging tests. This technique allows the localization of intrapancreatic insulinomas and represents useful tool for the diagnosis and surgical management of these tumors.