Research Article

Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents

Table 4

Absolute and relative frequencies (%) of alleles of SNPs for the presence or absence of clinical and laboratory changes evaluated as discrete variables ().

Genotype

ObeseLEP
AAAGGG

Yes5 (10.9)8.3930.015
No16 (100)58 (100)41 (89.1)

ObeseLEP
Presence of allele AAbsence of allele A

Yes5 (10.9)8.3930.007
No74 (100)41 (89.1)

Obese or overweightCYP2D6
CCCTTT

Yes25 (32.5)7 (19.4)5 (71.4)7.6950.021
No52 (67.5)29 (80.6)2 (28.6)

Obese or overweightCYP2D6
Presence of allele CAbsence of allele C

Yes32 (28.3)5 (71.4)5.7440.028
No81 (71.7)2 (28.6)

Obese or overweightHTR2C rs3813929 (Both genders)
Presence of allele GAbsence of allele G

Yes33 (35.1)4 (15.4)3.7140.054
No61 (64.9)22 (84.6)

Obese or overweightFemales
Presence of allele GAbsence of allele G

Yes8 (47.1)3.6970.115
No9 (52.9)5 (100)

Obese or overweightMales
Presence of allele GAbsence of allele G

Yes25 (32.5)4 (19)1.4260.289
No52 (67.5)17 (81)

HOMA-IRDRD2 rs1799978
AAAGGG

Changed12 (13.2)10 (34.5)6.6610.010
Normal79 (86.8)19 (65.5)

HOMA-IRDRD2 rs6277
Presence of allele TAbsence of allele T

Changed6 (10.9)16 (24.6)3.7380.053
Normal49 (89.1)49 (75.4)

HypertensionCYP2D6
CCCTTT

Yes3 (3.9)3 (8.3)2 (28.6)6.5090.039
No74 (96.1)33 (91.7)5 (71.4)

Abdominal circumferenceHTR2C rs6318 (both genders)
C, CCCGG, GG

Increased1 (3.8)3 (42.9)16 (18.4)6.7200.035
Normal25 (96.2)4 (57.1)71 (81.6)

Females
CCCGGG

Increased2 (40)7.4800.024
Normal5 (100)3 (60)12 (100)

Males
CG

Increased1 (4.5)17 (22.4)3.6150.066
Normal21 (95.5)59 (77.6)

Chi-square (GL = 1); Chi-square (GL = 2); Fisher’s exact test.