International Journal of Endocrinology / 2016 / Article / Tab 4 / Research Article
Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents Table 4 Absolute and relative frequencies (%) of alleles of SNPs for the presence or absence of clinical and laboratory changes evaluated as discrete variables (
).
Genotype Obese LEP AA AG GG Yes — — 5 (10.9) 8.393 0.015 No 16 (100) 58 (100) 41 (89.1) Obese LEP Presence of allele A Absence of allele A Yes — 5 (10.9) 8.393 0.007 No 74 (100) 41 (89.1) Obese or overweight CYP2D6 CC CT TT Yes 25 (32.5) 7 (19.4) 5 (71.4) 7.695 0.021 No 52 (67.5) 29 (80.6) 2 (28.6) Obese or overweight CYP2D6 Presence of allele C Absence of allele C Yes 32 (28.3) 5 (71.4) 5.744 0.028 No 81 (71.7) 2 (28.6) Obese or overweight HTR2C rs3813929 (Both genders) Presence of allele G Absence of allele G Yes 33 (35.1) 4 (15.4) 3.714 0.054 No 61 (64.9) 22 (84.6) Obese or overweight Females Presence of allele G Absence of allele G Yes 8 (47.1) — 3.697 0.115 No 9 (52.9) 5 (100) Obese or overweight Males Presence of allele G Absence of allele G Yes 25 (32.5) 4 (19) 1.426 0.289 No 52 (67.5) 17 (81) HOMA-IR DRD2 rs1799978 AA AG GG Changed 12 (13.2) 10 (34.5) — 6.661 0.010 Normal 79 (86.8) 19 (65.5) — HOMA-IR DRD2 rs6277 Presence of allele T Absence of allele T Changed 6 (10.9) 16 (24.6) 3.738 0.053 Normal 49 (89.1) 49 (75.4) Hypertension CYP2D6 CC CT TT Yes 3 (3.9) 3 (8.3) 2 (28.6) 6.509 0.039 No 74 (96.1) 33 (91.7) 5 (71.4) Abdominal circumference HTR2C rs6318 (both genders) C, CC CG G, GG Increased 1 (3.8) 3 (42.9) 16 (18.4) 6.720 0.035 Normal 25 (96.2) 4 (57.1) 71 (81.6) Females CC CG GG Increased — 2 (40) — 7.480 0.024 Normal 5 (100) 3 (60) 12 (100) Males C G Increased 1 (4.5) 17 (22.4) 3.615 0.066 Normal 21 (95.5) 59 (77.6)
Chi-square (GL = 1); Chi-square (GL = 2); Fisher’s exact test.