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Letter to the Editor
International Journal of Endocrinology
Volume 2016, Article ID 6169721, 6 pages
http://dx.doi.org/10.1155/2016/6169721
Research Article

Assessment of Bone Mineral Density in Male Patients with Chronic Obstructive Pulmonary Disease by DXA and Quantitative Computed Tomography

1Department of Radiology, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece
2Pulmonology Clinic, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece
3Department of Radiology, KAT Hospital, 14561 Athens, Greece
4Department of Nuclear Medicine, University Hospital of Larissa, University of Thessaly, School of Medicine, Biopolis, 41110 Larissa, Greece

Received 8 October 2015; Revised 23 December 2015; Accepted 31 January 2016

Academic Editor: Andreas Tomaschitz

Copyright © 2016 George Fountoulis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study is to identify the prevalence of osteoporosis in male patients with chronic obstructive pulmonary disease (COPD) by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and to compare the diagnostic abilities of the above methods. Thirty-seven male patients with established COPD were examined with DXA and standard QCT in lumbar spine, including L1, L2, and L3 vertebrae. -scores and bone mineral density values were calculated by DXA and QCT method, respectively. Comparative assessment of the findings was performed and statistical analysis was applied. QCT measurements found more COPD patients with impaired bone mineral density compared to DXA, namely, 13 (35.1%) versus 12 (32.4%) patients with osteopenia and 16 (43.2%) versus 9 (16.2%) patients with osteoporosis (). More vertebrae were found with osteoporosis by QCT compared to DXA (). The prevalence of osteoporosis among male patients with COPD is increased and DXA may underestimate this risk. QCT measurements have an improved discriminating ability to identify low BMD compared to DXA measurements because QCT is able to overcome diagnostic pitfalls including aortic calcifications and degenerative spinal osteophytes.