TY - JOUR A2 - Damante, Giuseppe AU - Hu, Zhigang AU - Zhao, Pengxin AU - Zhang, Kaili AU - Zang, Leilei AU - Liao, Haiying AU - Ma, Weiyuan PY - 2016 DA - 2016/06/29 TI - Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer SP - 6312529 VL - 2016 AB - Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. The aim of this study was to evaluate the changes and the predictive value of serum VAP-1 in patients with thyroid cancer. A total of 126 patients with thyroid nodules and 53 healthy controls participated in this study. The patients were further divided into subgroup 1 (69 cases with benign thyroid nodules) and subgroup 2 (57 cases with thyroid cancer). Serum VAP-1 was measured by time-resolved immunofluorometric assay. Diagnostic value of presurgical VAP-1 for thyroid cancer was conducted by receiver operating characteristic (ROC) curves. Serum levels of VAP-1 were significantly lower in thyroid cancer group than in healthy control and benign thyroid nodule groups. VAP-1 concentrations negatively correlated with serum thyroglobulin (Tg) levels in thyroid cancer patients (r=-0.81; p<0.001). The optimum cut-off value of VAP-1 was 456.6 ng/mL with a 77.4% specificity and 66.7% sensitivity for thyroid cancer diagnosis. Serum VAP-1 decreased in thyroid cancer patients and VAP-1 could be a potential useful adjunct biomarker in the diagnosis of thyroid cancer. SN - 1687-8337 UR - https://doi.org/10.1155/2016/6312529 DO - 10.1155/2016/6312529 JF - International Journal of Endocrinology PB - Hindawi Publishing Corporation KW - ER -