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International Journal of Endocrinology
Volume 2016, Article ID 7695648, 8 pages
http://dx.doi.org/10.1155/2016/7695648
Review Article

Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia

1Division of Biosciences, Research Department of Cell and Developmental Biology, University College London, London, UK
2Emergex Vaccines Ltd, Abingdon, Oxfordshire, UK
3Division of Infection and Immunity, University College London, London, UK
4Department of Biomedical Sciences and Human Oncology (DIMO), II Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy
5Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria, Negrar, Verona, Italy

Received 18 May 2016; Revised 26 July 2016; Accepted 4 August 2016

Academic Editor: Vittorio Unfer

Copyright © 2016 Sirilaksana Kunjara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Immunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia. Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism. Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. Intracellular action of these molecules is deeply affected by zinc, manganese, and calcium. To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease.