International Journal of Endocrinology / 2016 / Article / Tab 1 / Research Article
No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study Table 1 Descriptive characteristics of the study population.
Variables Entire study period Period 1 Period 2 Period 3 (1997–2005) (1997–1999) (2000–2002) (2003–2005) Patient Sibling Patient Sibling Patient Sibling Patient Sibling ( ( ( ( ( ( ( ( Variables of main interest GADA Median/Q1–Q3, U/mL 114/22–500 4/3–6 129/22–464 5/3–6 85/29–500 5/4–6 130/19–500 4/3–5 IA-2A Median/Q1–Q3, U/mL 188/0–250 0/0-0 145/0–250 0/0-0 191/0–250 0/0-0 229/0–250 0/0-0 Autoantibody status GADA pos. (>31 U/mL), 344/71.4 27/5.7 107/71.8 17/7.8 73/73.0 2/4.0 164/70.4 8/3.8 IA-2A pos. (>5 U/mL), 322/66.8 10/2.1 93/62.4 6/2.8 67/67.0 3/6.0 162/69.5 1/0.5 GADA & IA-2A pos., 244/50.6 8/1.7 71/47.7 6/2.8 52/52.0 1/2.0 121/51.9 1/0.5 Basic characteristics Gender Female, 227/47.1 212/44.4 74/49.7 99/45.6 46/46.0 18/36.0 107/45.9 95/45.2 Age at blood sampling Median/Q1–Q3, years 10.4/7.4–12.5 10.3/7.8–12.8 10.8/7.2–12.7 10.6/7.9–12.9 9.9/7.1–12.8 9.8/7.6–12.2 10.3/7.5–12.4 10.2/7.6–12.8 Season when blood was sampled, Winter 121/25.1 124/26.0 38/25.5 62/28.6 31/31.0 17/34.0 52/22.3 46/21.4 Spring 123/25.5 123/25.8 38/25.5 54/24.9 25/25.0 12/24.0 60/25.8 57/27.1 Summer 109/22.6 133/27.9 30/20.1 57/26.3 24/24.0 12/24.0 55/23.6 64/30.5 Autumn 129/26.8 97/20.3 43/28.9 46/20.3 20/20.0 9.18.0 66/28.3 44/21.0 HLA risk groups High 312/70.1 228/50.1 84/63.2 112/53.0 69/72.6 20/41.7 159/73.3 96/49.0 Moderate 66/14.8 43/9.5 30/22.6 19/9.0 11/11.6 7/14.6 25/11.5 17/8.7 Low/protective 67/15.1 184/40.4 19/14.3 80/37.9 15/15.8 21/43.8 33/15.2 83/42.4
HLA-DQB1 genotypes are collapsed into risk categories, which are seen below.
