No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study

Table 2

Estimated relative differences in autoantibody levels according to the covariates in the adjusted model.

Outcome	Variable	Level	RC (95% CI)	value
GADA	Status	Patient	17.71	<0.0001
		Sibling	1
	Gender	Females	1.12 (0.91; 1.38)	0.29
		Male	1
	Age	10+ yrs	1.92 (1.22; 3.02)	0.005
		5–10 yrs	1.62 (1.01; 2.59)	0.045
		0–5 yrs	1
	Period	2003–2005	0.87 (0.70; 1.09)	0.23
		2000–2002	1.04 (0.76; 1.42)	0.82
		1997–1999	1
	Season	Spring	1.12 (0.85; 1.48)	0.41
		Summer	0.91 (0.69; 1.21)	0.53
		Autumn	0.89 (0.66; 1.22)	0.47
		Winter	1
	HLA risk	Low	0.72 (0.58; 0.90)	0.004
		Moderate	1.39 (0.96; 2.01)	0.083
		High	1
IA-2A	Status	Patient		<0.0001
		Sibling	1
	Gender	Females	0.24 (0.06; 1.07)	0.06
		Male	1
	Age	10+ yrs	3.43 (0.24; 48.11)	0.36
		5–10 yrs	6.39 (0.42; 97.17)	0.18
		0–5 yrs	1
	Period	2003–2005	0.68 (0.13; 3.56)	0.97
		2000–2002	1.05 (0.10; 10.72)	0.65
		1997–1999	1
	Season	Spring	0.69 (0.09; 5.55)	0.73
		Summer	2.38 (0.26; 21.39)	0.44
		Autumn	0.34 (0.04; 2.93)	0.33
		Winter	1
	HLA risk	Low	0.030 (0.004; 0.21)	0.0005
		Moderate	0.014 (0.001; 0.15)	0.0005
		High	1

Bold letters indicate significance at a 5% level.
HLA-DQB1 genotypes are collapsed into risk categories, which are seen below.
HLA-DQB1 allele_1/allele_2: 06 : 02/03 : 02, 06 : 02/02, 06 : 03/99 : 99, 03 : 01/99 : 99, 06 : 02/03 : 01, 06 : 03/03 : 01, 06 : 04/03 : 01, 06 : 03/02, 03 : 04/99 : 99, 03 : 04/02, 06 : 02/03 : 04, 99 : 99/99 : 99.
HLA-DQB1 allele_1/allele_2: 03 : 01/02, 06 : 03/03 : 02, 02/99 : 99, 06 : 04/02, 06 : 04/99 : 99, 03 : 01/03 : 02. 06 : 04/03 : 04.
HLA-DQB1 allele_1/allele_2: 03 : 02/99 : 99, 03 : 02/02, 06 : 04/03 : 02.
99 : 99 = remaining alleles.