Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2016 (2016), Article ID 8483405, 7 pages
http://dx.doi.org/10.1155/2016/8483405
Research Article

Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China

1Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China
2Health Management Center, Zhejiang Hospital, Hangzhou 310013, China
3Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China

Received 15 September 2016; Revised 31 October 2016; Accepted 8 November 2016

Academic Editor: Małgorzata Kotula-Balak

Copyright © 2016 Mei-Fang Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coronary heart disease (CHD) and stroke are common complications of type 2 diabetes mellitus (T2DM). We aimed to explore the differences in the risks of CHD and stroke between Chinese women and men with T2DM and their association with metabolic syndrome (MS). This study included 1514 patients with T2DM. The Asian Guidelines of ATPIII (2005) were used for MS diagnosis, and the UKPDS risk engine was used to evaluate the 10-year CHD and stroke risks. Women had lower CHD risk (15.3% versus 26.3%), fatal CHD risk (11.8% versus 19.0%), stroke risk (8.4% versus 10.3%), and fatal stroke risk (1.4% versus 1.6%) compared with men with T2DM (–0.001). The CHD risk (28.4% versus 22.6%, ) was significantly higher in men with MS than in those without MS. The CHD (16.2% versus 11.0%, ) and stroke risks (8.9% versus 5.8%, ) were higher in women with MS than in those without MS. In conclusion, our findings indicated that Chinese women with T2DM are less susceptible to CHD and stroke than men. Further, MS increases the risk of both these events, highlighting the need for comprehensive metabolic control in T2DM.