TY - JOUR A2 - Unfer, Vittorio AU - Lauretta, Rosa AU - Lanzolla, Giulia AU - Vici, Patrizia AU - Mariani, Luciano AU - Moretti, Costanzo AU - Appetecchia, Marialuisa PY - 2016 DA - 2016/09/20 TI - Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk SP - 8671762 VL - 2016 AB - Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment. Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers. Several lines of evidence support the protection against cancer exerted by dietary inositol, in particular inositol hexaphosphate. Metformin, thiazolidinediones, and myoinositol postreceptor signaling may exhibit direct inhibitory effects on cancer cell growth. AMPK, the main molecular target of metformin, is emerging as a target for cancer prevention and treatment. PCOS may be correlated to an increased risk for developing ovarian and endometrial cancer (up to threefold). Several studies have demonstrated an increase in mortality rate from ovarian cancer among overweight/obese PCOS women compared with normal weight women. Long-term use of metformin has been associated with lower rates of ovarian cancer. Considering the evidence supporting a higher risk of gynaecological cancer in PCOS women, we discuss the potential use of insulin-sensitizers as a potential tool for chemoprevention, hypothesizing a possible rationale through which insulin-sensitizers may inhibit tumourigenesis. SN - 1687-8337 UR - https://doi.org/10.1155/2016/8671762 DO - 10.1155/2016/8671762 JF - International Journal of Endocrinology PB - Hindawi Publishing Corporation KW - ER -