Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk

Table 1

Metformin and endometrial proliferative pathology.

Author	Ref	Year	Study	Results
Session et al.	[10]	2003	Human clinical study	MTF regresses atypical endometrial hyperplasia in one patient
Legro et al.	[11]	2007	Human clinical study	MTF resolved simple hyperplasia in two patients
Shen et al.	[12]	2008	Human clinical study	MTF regresses atypical endometrial hyperplasia in two women
Cantrell et al.	[13]	2010	Endometrial cell line experimental	MTF is a potent inhibitor of cell proliferation in endometrial cancer cell lines
Tan et al.	[14]	2011	Human experimental study	MTF reduces in vitro endometrial invasion
Li et al.	[15]	2014	Human clinical study	MTF reverts stage IA endometrial carcinoma into normal in five young PCOS patients

MTF: metformin.