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International Journal of Endocrinology
Volume 2017, Article ID 1087017, 13 pages
https://doi.org/10.1155/2017/1087017
Research Article

Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus

1Department of Metabolism & Endocrinology, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
2Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China

Correspondence should be addressed to Yun-Zhi Feng; moc.361@303066zyf and Hou-De Zhou; nc.ude.usc@uohzeduoh

Received 9 April 2017; Revised 31 July 2017; Accepted 16 August 2017; Published 4 October 2017

Academic Editor: Darío Acuña-Castroviejo

Copyright © 2017 Yue Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Fig. 1 A schematic diagram showing the antimicrobial and anti-inflammatory effects of BPI fold containing family A, member 1 (BPIFA1). BPIFA1 has antibacterial properties since it can bind bacterial lipopolysaccaride (LPS) and is likely to be bacteriostatic. Moreover, BPIFA1 could modulate the inflammatory response through the regulation of the Toll-like receptor (TLR) 9/NF-κB signaling pathway, which might further stimulate the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). BPIFA1 can also directly regulate the proinflammatory cytokines such as IL-6 and TNF-α stimulated by the binding of LPS.

  1. Supplementary Material