Combination Therapy with a Sodium-Glucose Cotransporter 2 Inhibitor and a Dipeptidyl Peptidase-4 Inhibitor Additively Suppresses Macrophage Foam Cell Formation and Atherosclerosis in Diabetic Mice

Figure 4

Atherosclerotic plaque formation in streptozotocin-induced diabetic apolipoprotein E-null mice with indicated treatments. (a) Representative images of the aortic root stained with oil red O at 40x magnification. (b) Average oil red O-positive area in the aortic root. (c) Representative images of the aortic root immunostained with antimouse MOMA-2 antibody at 40x magnification. (d) Average MOMA-2-positive area in the aortic root. (e) Representative images of atherosclerotic plaque lesions on the surface of the whole aorta stained with oil red O. The yellow arrows show notable atherosclerotic lesions. (f) Average percentage of oil red O-positive area to the total area of the aorta. .

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