Review Article

Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know

Table 2

Preferred screening tests in special circumstances [2, 9, 15].

SituationsTest preferredTest not preferred

Cyclic Cushing’s syndrome [21]UFC or LNSCDST
Mild Cushing’s syndrome [21]LNSC or DSTUFC
Pseudo Cushing’s syndrome [21]LNSC or DSTUFC
CS patients on antiepileptics [21]UFC or LNSCDST
Adrenal incidentaloma [21]DSTUFC or LNSC
Pregnancy [21]UFCDST, LNSC
Severe chronic kidney disease [21]DST or LNSCUFC
Low pretest probability [15]UFC
High pretest probability [15]LNSC

UFC: urinary free cortisol; LNSC: late-night salivary cortisol; DST: dexamethasone suppression test.