Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2017, Article ID 1659071, 8 pages
https://doi.org/10.1155/2017/1659071
Research Article

A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder

1Clinical Division of Nephrology, Medical University of Graz, Graz, Austria
2Clinical Division of Cardiology, Medical University of Graz, Graz, Austria
3Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
4Clinical Division of Endocrinology and Diabetes, Medical University of Graz, Graz, Austria
5Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria

Correspondence should be addressed to Philipp Eller; ta.zarginudem@relle.ppilihp

Received 5 June 2017; Revised 31 August 2017; Accepted 11 September 2017; Published 14 December 2017

Academic Editor: Rosaria Meccariello

Copyright © 2017 Bianca Frauscher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Collins, R. N. Foley, B. Chavers et al., “United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States,” American Journal of Kidney Diseases, vol. 59, no. 1, Supplement 1, p. A7, e1–420, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. S. Go, G. M. Chertow, D. J. Fan, C. E. McCulloch, and C. Y. Hsu, “Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization,” The New England Journal of Medicine, vol. 351, no. 13, pp. 1296–1305, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. G. M. London, “Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function,” Journal of the American Society of Nephrology, vol. 14, Supplement 4, no. 9, pp. S305–S309, 2003. View at Publisher · View at Google Scholar
  4. S. A. Jamal, O. Ljunggren, C. Stehman-Breen et al., “Effects of denosumab on fracture and bone mineral density by level of kidney function,” Journal of Bone and Mineral Research, vol. 26, no. 8, pp. 1829–1835, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. L. Nickolas, M. B. Leonard, and E. Shane, “Chronic kidney disease and bone fracture: a growing concern,” Kidney International, vol. 74, no. 6, pp. 721–731, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Vervloet and M. Cozzolino, “Vascular calcification in chronic kidney disease: different bricks in the wall?” Kidney International, vol. 91, no. 4, pp. 808–817, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. G. M. London, A. P. Guerin, S. J. Marchais, F. Metivier, B. Pannier, and H. Adda, “Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality,” Nephrology Dialysis Transplantation, vol. 18, no. 9, pp. 1731–1740, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group, “KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD),” Kidney International Supplement, vol. 76, no. 113, pp. S1–130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Moe, T. Drüeke, J. Cunningham et al., “Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO),” Kidney International, vol. 69, no. 11, pp. 1945–1953, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Yamada and C. M. Giachelli, “Vascular calcification in CKD-MBD: roles for phosphate, FGF23, and klotho,” Bone, vol. 100, pp. 87–93, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Alem, D. J. Sherrard, D. L. Gillen et al., “Increased risk of hip fracture among patients with end-stage renal disease,” Kidney International, vol. 58, no. 1, pp. 396–399, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. S. M. Kim, J. Long, M. Montez-Rath, M. Leonard, and G. M. Chertow, “Hip fracture in patients with non-dialysis-requiring chronic kidney disease,” Journal of Bone and Mineral Research, vol. 31, no. 10, pp. 1803–1809, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Cejka, D. Parada-Rodriguez, S. Pichler et al., “Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease,” Kidney International, vol. 90, no. 4, pp. 828–834, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Jansen, S. Duijst, S. Mahakena et al., “ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 9, pp. 1985–1989, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Meng, I. Vera, N. Che et al., “Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 11, pp. 4530–4535, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. T. G. M. F. Gorgels, X. Hu, G. L. Scheffer et al., “Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum,” Human Molecular Genetics, vol. 14, no. 13, pp. 1763–1773, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Sedej, A. Schmidt, M. Denegri et al., “Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload,” Journal of the American College of Cardiology, vol. 63, no. 15, pp. 1569–1579, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. R. F. Gagnon and B. Gallimore, “Characterization of a mouse model of chronic uremia,” Urological Research, vol. 16, no. 2, pp. 119–126, 1988. View at Publisher · View at Google Scholar · View at Scopus
  19. A. H. Kirsch, N. Smaczny, V. Riegelbauer et al., “Regulatory T cells improve nephrocalcinosis but not dystrophic cardiac calcinosis in DBA/2 mice,” The American Journal of Pathology, vol. 183, no. 2, pp. 382–390, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Eller, K. Eller, A. H. Kirsch et al., “A murine model of phosphate nephropathy,” The American Journal of Pathology, vol. 178, no. 5, pp. 1999–2006, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. I. G. Nikolov, N. Joki, T. Nguyen-Khoa et al., “Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure,” Bone, vol. 47, no. 1, pp. 156–163, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. E. A. González, R. J. Lund, K. J. Martin et al., “Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7,” Kidney International, vol. 61, no. 4, pp. 1322–1331, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. A. H. Kirsch, A. Kirsch, K. Artinger et al., “Heterogeneous susceptibility for uraemic media calcification and concomitant inflammation within the arterial tree,” Nephrology Dialysis Transplantation, vol. 30, no. 12, pp. 1995–2005, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Leroux-Berger, I. Queguiner, T. T. Maciel, A. Ho, F. Relaix, and H. Kempf, “Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin,” Journal of Bone and Mineral Research, vol. 26, no. 7, pp. 1543–1553, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. F. G. Graciolli, K. R. Neves, F. Barreto et al., “The complexity of chronic kidney disease-mineral and bone disorder across stages of chronic kidney disease,” Kidney International, vol. 91, no. 6, pp. 1436–1446, 2017. View at Publisher · View at Google Scholar