Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation

Figure 1

NLRP3 inflammasome activation pathways. ASC: apoptotic-associated speck-like protein containing a caspase recruitment domain; CPPD: calcium pyrophosphate dihydrate; DAMP: danger-associated molecular pattern; LPS: lipopolysaccharide; MDP: muramyl dipeptide; MAMP: microbial-associated molecular pattern; MSU: monosodium urate; ROS: reactive oxygen species; TXNIP: thioredoxin-interacting protein; Casp-1: caspase-1. From Conforti-Andreoni et al. [126] (reprinted by permission—Cellular & Molecular Immunology license number 4125310130103).