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International Journal of Endocrinology
Volume 2017, Article ID 1925305, 7 pages
https://doi.org/10.1155/2017/1925305
Clinical Study

The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

1Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan
2Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
3Department of Metabolism & Atherosclerosis, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
4Shiraiwa Medical Clinic, 4-10-24 Houzenji, Kashiwara, Osaka 582-0005, Japan
5Department of Medicine, Diabetology & Endocrinology, Juntendo Tokyo Koto Geriatric Medical Center, Shinsuna 3-3-20, Koto-ku, Tokyo 136-0075, Japan
6Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

Correspondence should be addressed to Tomoya Mita; pj.ca.odnetnuj@m-mot

Received 1 October 2016; Accepted 24 November 2016; Published 17 January 2017

Academic Editor: Michael Horowitz

Copyright © 2017 Tomoya Mita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Action to Control Cardiovascular Risk in Diabetes Study G, H. C. Gerstein, M. E. Miller et al., “Effects of intensive glucose lowering in type 2 diabetes,” The New England Journal of Medicine, vol. 358, no. 24, pp. 2545–2559, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. Group AC, A. Patel, S. MacMahon et al., “Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes,” The New England Journal of Medicine, vol. 358, no. 24, pp. 2560–2572, 2008. View at Publisher · View at Google Scholar
  3. W. Duckworth, C. Abraira, T. Moritz et al., “Glucose control and vascular complications in veterans with type 2 diabetes,” The New England Journal of Medicine, vol. 360, no. 2, pp. 129–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. “The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group,” The New England Journal of Medicine, vol. 329, no. 14, pp. 977–986, 1993. View at Publisher · View at Google Scholar
  5. A. N. Jacob, K. Salinas, B. Adams-Huet, and P. Raskin, “Weight gain in type 2 diabetes mellitus,” Diabetes, Obesity & Metabolism, vol. 9, no. 3, pp. 386–393, 2007. View at Publisher · View at Google Scholar
  6. L. Lundby-Christensen, L. Tarnow, T. W. Boesgaard et al., “Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus-the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) Trial,” British Medical Journal Open, vol. 6, no. 2, Article ID e008376, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Yasunari, K. Takeno, H. Funayama et al., “Efficacy of pioglitazone on glycemic control and carotid intima-media thickness in type 2 diabetes patients with inadequate insulin therapy,” Journal of Diabetes Investigation, vol. 2, no. 1, pp. 56–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Mita, N. Katakami, T. Shiraiwa et al., “Sitagliptin attenuates the progression of carotid intima-media thickening in insulin-treated patients with type 2 diabetes: the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): a randomized controlled trial,” Diabetes Care, vol. 39, no. 3, pp. 455–464, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. J. L. Fleg, M. Mete, B. V. Howard et al., “Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial,” Journal of the American College of Cardiology, vol. 52, no. 25, pp. 2198–2205, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. R. Langenfeld, T. Forst, C. Hohberg et al., “Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study,” Circulation, vol. 111, no. 19, pp. 2525–2531, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Yamasaki, N. Katakami, S. Furukado et al., “Long-term effects of pioglitazone on carotid atherosclerosis in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity,” Journal of Atherosclerosis and Thrombosis, vol. 17, no. 11, pp. 1132–1140, 2010. View at Publisher · View at Google Scholar
  12. K. Esposito, D. Giugliano, F. Nappo, R. Marfella, and Campanian Postprandial Hyperglycemia Study G, “Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus,” Circulation, vol. 110, no. 2, pp. 214–219, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Matsubara, S. Sugiyama, K. Sugamura et al., “A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice,” Journal of the American College of Cardiology, vol. 59, no. 3, pp. 265–276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Arakawa, T. Mita, K. Azuma et al., “Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4,” Diabetes, vol. 59, no. 4, pp. 1030–1037, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Ervinna, T. Mita, E. Yasunari et al., “Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice,” Endocrinology, vol. 154, no. 3, pp. 1260–1270, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Zeng, C. Li, M. Guan et al., “The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms,” Cardiovascular Diabetology, vol. 13, 32 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus